ArticleBiophysical journal2014
Porosity controls spread of excitation in tectorial membrane traveling waves.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Quantitative Evaluation of the 3D Anatomy of the Human Osseous Spiral Lamina Using MicroCT.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Visualizing Collagen Fibrils in the Cochlea's Tectorial and Basilar Membranes Using a Fluorescently Labeled Collagen-Binding Protein Fragment.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.Biophysical journal · 2021Article
- Two-tone distortion in reticular lamina vibration of the living cochlea.Communications biology · 2020Article
- The Tectorial Membrane: Mechanical Properties and Functions.Cold Spring Harbor perspectives in medicine · 2019Review
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Anisotropic Material Properties of Wild-Type and TectbBiophysical journal · 2019Article
- Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections.Physical review letters · 2019Article
- Accelerated Age-Related Degradation of the Tectorial Membrane in theFrontiers in molecular neuroscience · 2019Article
- Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea.Cell reports · 2018Article
- Motion microscopy for visualizing and quantifying small motions.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Geometric Requirements for Tectorial Membrane Traveling Waves in the Presence of Cochlear Loads.Biophysical journal · 2017Article
- A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics.Nature communications · 2017Article
- Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.Journal of structural biology · 2016Article
- Longitudinal spread of mechanical excitation through tectorial membrane traveling waves.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.Biophysical journal · 2015Article
- Modified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix.Biophysical journal · 2015Article
- Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cochlear frequency selectivity plays a key role in our ability to understand speech, and is widely believed to be associated with cochlear amplification. However, genetic studies targeting the tectorial membrane (TM) have demonstrated both sharper and broader tuning with no obvious changes in hair bundle or somatic motility mechanisms. For example, cochlear tuning of Tectb(-/-) mice is significantly sharper than that of Tecta(Y1870C/+) mice, even though TM stiffnesses are similarly reduced relative to wild-type TMs. Here we show that differences in TM viscosity can account for these differences in tuning. In the basal cochlear turn, nanoscale pores of Tecta(Y1870C/+) TMs are significantly larger than those of Tectb(-/-) TMs. The larger pore size reduces shear viscosity (by ∼70%), thereby reducing traveling wave speed and increasing spread of excitation. These results demonstrate the previously unrecognized importance of TM porosity in cochlear and neural tuning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.