ArticleBiophysical journal2014
Effect of the attachment of the tectorial membrane on cochlear micromechanics and two-tone suppression.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements.Biophysical journal · 2024Article
- Advective mass transport along the cochlear coil.AIP conference proceedings · 2024Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- Broad nonlinearity in reticular lamina vibrations requires compliant organ of Corti structures.Biophysical journal · 2023Article
- Deiters Cells Act as Mechanical Equalizers for Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- An outer hair cell-powered global hydromechanical mechanism for cochlear amplification.Hearing research · 2022Article
- The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- A role for tectorial membrane mechanics in activating the cochlear amplifier.Scientific reports · 2020Article
- Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound.Science advances · 2020Article
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- Power Dissipation in the Cochlea Can Enhance Frequency Selectivity.Biophysical journal · 2019Article
- Probing hair cell's mechano-transduction using two-tone suppression measurements.Scientific reports · 2019Article
- Drug Diffusion Along an Intact Mammalian Cochlea.Frontiers in cellular neuroscience · 2019Article
- Forward and Reverse Waves: Modeling Distortion Products in the Intracochlear Fluid Pressure.Biophysical journal · 2018Article
- Hydrostatic measurement and finite element simulation of the compliance of the organ of Corti complex.The Journal of the Acoustical Society of America · 2018Article
- Modeling signal propagation in the human cochlea.The Journal of the Acoustical Society of America · 2017Article
- Two passive mechanical conditions modulate power generation by the outer hair cells.PLoS computational biology · 2017Article
- Stimulus Frequency Otoacoustic Emissions Provide No Evidence for the Role of Efferents in the Enhancement Effect.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanical stimulation of the outer hair cell hair bundle (HB) is a key step in nonlinear cochlear amplification. We show how two-tone suppression (TTS), a hallmark of cochlear nonlinearity, can be used as an indirect measure of HB stimulation. Using two different nonlinear computational models of the cochlea, we investigate the effect of altering the mechanical load applied by the tectorial membrane (TM) on the outer hair cell HB. In the first model (TM-A model), the TM is attached to the spiral limbus (as in wild-type animals); in the second model (TM-D model), the TM is detached from the spiral limbus (mimicking the cochlea of Otoa(EGFP/EGFP) mutant mice). As in recent experiments, model simulations demonstrate that the absence of the TM attachment does not preclude cochlear amplification. However, detaching the TM alters the mechanical load applied by the TM on the HB at low frequencies and therefore affects TTS by low-frequency suppressors. For low-frequency suppressors, the suppression threshold obtained with the TM-A model corresponds to a constant suppressor displacement on the basilar membrane (as in experiments with wild-type animals), whereas it corresponds to a constant suppressor velocity with the TM-D model. The predictions with the TM-D model could be tested by measuring TTS on the basilar membrane of the Otoa(EGFP/EGFP) mice to improve our understanding of the fundamental workings of the cochlea.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.