ArticleNanoscale research letters2014
Capillary-driven surface-enhanced Raman scattering (SERS)-based microfluidic chip for abrin detection.
Article in Nanoscale research letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy-Lateral Flow Assay Method for Abrin and Ricin Detection.Toxins · 2024Article
- Performance of Classification Models of Toxins Based on Raman Spectroscopy Using Machine Learning Algorithms.Molecules (Basel, Switzerland) · 2023Article
- A New Method for Abrin Detection Based on the Interaction between Target Molecules and Fluorescently Labeled Aptamers on Magnetic Microspheres.Materials (Basel, Switzerland) · 2022Article
- Bio-barcode triggered isothermal amplification in a fluorometric competitive immunoassay for the phytotoxin abrin.Mikrochimica acta · 2020Article
- Detection of Abrin by Electrochemiluminescence Biosensor Based on Screen Printed Electrode.Sensors (Basel, Switzerland) · 2018Article
- Surface enhanced Raman scattering (SERS) based biomicrofluidics systems for trace protein analysis.Biomicrofluidics · 2018Review
- The tuning of the plasmon resonance of the metal nanoparticles in terms of the SERS effect.Colloid and polymer science · 2018Article
- Smartphone-Based Dual-Modality Imaging System for Quantitative Detection of Color or Fluorescent Lateral Flow Immunochromatographic Strips.Nanoscale research letters · 2017Article
- Gold Nanoparticles as a Direct and Rapid Sensor for Sensitive Analytical Detection of Biogenic Amines.Nanoscale research letters · 2017Article
- Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection.Nanoscale research letters · 2015Article
- Increased SERS detection efficiency for characterizing rare events in flow.Analytical chemistry · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we firstly demonstrate the design and the proof-of-concept use of a capillary-driven surface-enhanced Raman scattering (SERS)-based microfluidic chip for abrin detection. The micropillar array substrate was etched and coated with a gold film by microelectromechanical systems (MEMS) process to integrate into a lateral flow test strip. The detection of abrin solutions of various concentrations was performed by the as-prepared microfluidic chip. It was shown that the correlation between the abrin concentration and SERS signal was found to be linear within the range of 0.1 ng/mL to 1 μg/mL with a limit of detection of 0.1 ng/mL. Our microfluidic chip design enhanced the operability of SERS-based immunodiagnostic techniques, significantly reducing the complication and cost of preparation as compared to previous SERS-based works. Meanwhile, this design proved the superiority to conventional lateral flow test strips in respect of both sensitivity and quantitation and showed great potential in the diagnosis and treatment for abrin poisoning as well as on-site screening of abrin-spiked materials.
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Registered trials
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