ArticleArthritis research & therapy2014
Bone fragility in sarcoidosis and relationships with calcium metabolism disorders: a cross sectional study on 142 patients.
Article in Arthritis research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 49 citations in OpenAlex.
- Osteoporotic bone fracture risk assessment in Latvian patients with newly diagnosed sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity.Aging clinical and experimental research · 2023Article
- Safety of corticosteroid therapy in sarcoidosis treatment.Frontiers in drug safety and regulation · 2023Review
- Bone fragility and sarcoidosis: An underestimated relationship.Frontiers in medicine · 2022Article
- Hypercalciuria in Sarcoidosis: A Specific Biomarker With Clinical Utility.Frontiers in medicine · 2020Article
- The role of vitamin D in sarcoidosis.Faculty reviews · 2020Review
- Bone Mineral Loss and Fracture in Sarcoidosis: A Systematic Review and Meta-Analysis.Archives of rheumatology · 2019Article
- Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers.Molecular genetics & genomic medicine · 2019Article
- Serum and urinary calcium level in Latvian patients with sarcoidosis.Reumatologia · 2018Article
- Vitamin D status in sarcoidosis: a cross-sectional study.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Use of systemic glucocorticoids and the risk of major osteoporotic fractures in patients with sarcoidosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976-2013.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- [Musculoskeletal manifestations of sarcoidosis].Zeitschrift fur Rheumatologie · 2017Review
- Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Goldilocks, vitamin D and sarcoidosis.Arthritis research & therapy · 2014Article
- High-dose Vitamin D Supplementation Precipitating Hypercalcemic Crisis in Granulomatous Disorders.Indian journal of endocrinology and metabolismArticle
- Sarcoidosis and calcium homeostasis disturbances-Do we know where we stand?Chronic respiratory diseaseReview
- Key messages from a rare case of annular sarcoidosis of scalp.Indian dermatology online journalArticle
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9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation. The objective of this study was to evaluate the risk factors for low bone mineral density (BMD) and fractures in sarcoidosis. In particular, we aimed to determine the link among bone fragility and calcium and vitamin D metabolism in this population.
methodsWe performed a cross-sectional analysis on 142 consecutive patients with histologically proven sarcoidosis. BMD and prevalence of vertebral fractures on X-rays were assessed and the association with potential risk factors was studied by regression analysis.
resultsFragility fractures occurred in 23.5% of patients, despite a normal mean BMD in the study population. In a multivariate analysis, low dietary calcium, fracture, age, gender and menopause were associated with increased risk of low BMD. Low dietary calcium, high current corticosteroid dose and low creatinine clearance were associated with increased risk of fracture. Serum 25(OH)D between 10 and 20 ng/ml was significantly associated with higher BMD. Conversely, values greater than 20 ng/ml were associated with increased risk of fracture. Serum 25(OH)D level was inversely correlated with disease activity. Of note, vitamin D supplements increased serum 25(OH)D in a dose-dependent manner but had no effect on serum calcium level.
conclusionsSarcoidosis patients have a high risk of fracture despite not having a lowered BMD suggesting that other independent factors are involved. Current corticosteroid dose, low dietary calcium and serum 25(OH)D levels are associated with bone fragility. In sarcoidosis, calcium and vitamin D supplementation might be warranted, but desirable 25(OH)D serum levels might be lower than those advised for the general population.
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