Trial reportAlcoholism, clinical and experimental research2014
Cardiac reactivity during the ascending phase of acute intravenous alcohol exposure and association with subjective perceptions of intoxication in social drinkers.
Trial report in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020Pooled it
- Real-world effects of alcohol on heart rate, sleep, and physical activity by age and sex.PLOS digital health · 2026Article
- Haven't lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Sex, Gender, and Alcohol Use: Implications for Women and Low-Risk Drinking Guidelines.International journal of environmental research and public health · 2022Review
- Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers.Brain sciences · 2021Article
- Assessment of Skin Blood Flow Following Acute Intravenous Alcohol, and Association with Subjective Perceptions, in Social Drinkers.Alcoholism, clinical and experimental research · 2019Article
- Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications.Addiction biology · 2018Article
- Impact of Alcohol Consumption on Atrial Fibrillation Outcomes Following Pulmonary Vein Isolation.Journal of atrial fibrillation · 2016Article
- A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking.Current drug abuse reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe aim of this study was to characterize cardiac reactivity measures, heart rate (HR), and heart rate variability (HRV), following acute intravenous (IV) alcohol administration and their association with subjective responses in social drinkers.
methodsTwenty-four subjects (11 females) received IV alcohol infusions to attain and clamp the breath alcohol concentration (BrAC) at 50 mg% or placebo in separate sessions. Serial 5-minute cardiac recordings at baseline and during the infusion were analyzed to obtain frequency and time domain cardiac measures. Self-reported subjective perceptions were also obtained at the same time points.
resultsHR showed significant decreases from baseline, while the HRV measure pNN50 showed steady increases during the ascending phase of alcohol infusion. HR was inversely correlated with pNN50 across time and treatment. There was a significant association of HR with subjective feelings of high, intoxication, feeling drug effects, and liking drug effects across time during the ascending phase.
conclusionsAcute IV alcohol resulted in decreases in HR and increases in HRV consistent with autonomic parasympathetic activation. The association of these changes with subjective responses suggests that cardiac reactivity may serve as a physiological marker of subjective alcohol effects. This study broadens the understanding of acute cardiovascular effects of alcohol and clinically significant cardiac conditions such as arrhythmia and cardiomyopathy associated with chronic alcohol drinking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.