ArticleACS nano2014
Programming nanopore ion flow for encoded multiplex microRNA detection.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 104 citations in OpenAlex.
- Background-Free Nanopore Decoding of microRNA Expression Patterns Using Circular Diagnostic DNA.Analytical chemistry · 2026Article
- Quantitative and Multiplexing Analysis of MicroRNAs by Direct Full-Length Sequencing in Nanopores.Journal of the American Chemical Society · 2025Article
- Real-time label-free detection of dynamic aptamer-small molecule interactions using a nanopore nucleic acid conformational sensor.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Nanopore Single-molecule Analysis of Biomarkers: Providing Possible Clues to Disease Diagnosis.Trends in analytical chemistry : TRAC · 2023Article
- Pattern Recognition of microRNA Expression in Body Fluids Using Nanopore Decoding at Subfemtomolar Concentrations.JACS Au · 2022Article
- A nanopore interface for higher bandwidth DNA computing.Nature communications · 2022Article
- Translocation Behaviors of Synthetic Polyelectrolytes through Alpha-Hemolysin (α-HL) andJournal of the Electrochemical Society · 2022Article
- Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum.Nature communications · 2021Article
- Influence of Electrolyte Concentration on Single-Molecule Sensing of Perfluorocarboxylic Acids.Frontiers in chemistry · 2021Article
- A Lipid-Bilayer-On-A-Cup Device for Pumpless Sample Exchange.Micromachines · 2020Article
- Sequence-Specific Detection of DNA Strands Using a Solid-State Nanopore Assisted by Microbeads.Micromachines · 2020Article
- Resistive amplitude fingerprints during translocation of linear molecules through charged solid-state nanopores.The Journal of chemical physics · 2020Article
- Lateral Flow Test for Visual Detection of Multiple MicroRNAs.Sensors and actuators. B, Chemical · 2018Article
- Label-Free Detection of DNA Mutations by Nanopore Analysis.ACS applied materials & interfaces · 2018Article
- Membrane protein-based biosensors.Journal of the Royal Society, Interface · 2018Review
- Electrochemical nucleic acid detection based on parallel structural dsDNA/recombinant azurin hybrid.Biosensors & bioelectronics · 2017Article
- Nanopore electric snapshots of an RNA tertiary folding pathway.Nature communications · 2017Article
- Polycationic Probe-Guided Nanopore Single-Molecule Counter for Selective miRNA Detection.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Article
- Future microfluidic and nanofluidic modular platforms for nucleic acid liquid biopsy in precision medicine.Biomicrofluidics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many efforts are being made in translating the nanopore into an ultrasensitive single-molecule platform for various genetic and epigenetic detections. However, compared with current approaches including PCR, the low throughput limits the nanopore applications in biological research and clinical settings, which usually requires simultaneous detection of multiple biomarkers for accurate disease diagnostics. Herein we report a barcode probe approach for multiple nucleic acid detection in one nanopore. Instead of directly identifying different targets in a nanopore, we designed a series of barcode probes to encode different targets. When the probe is bound with the target, the barcode group polyethylene glycol attached on the probe through click chemistry can specifically modulate nanopore ion flow. The resulting signature serves as a marker for the encoded target. Therefore counting different signatures in a current recording allows simultaneous analysis of multiple targets in one nanopore. The principle of this approach was verified by using a panel of cancer-derived microRNAs as the target, a type of biomarker for cancer detection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.