ArticleCerebral cortex (New York, N.Y. : 1991)2015
Strengthening of Direction Selectivity by Broadly Tuned and Spatiotemporally Slightly Offset Inhibition in Mouse Visual Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Cortical direction selectivity increases from the input to the output layers of visual cortex.PLoS biology · 2025Article
- Cross-modal enhancement of defensive behavior via parabigemino-collicular projections.Current biology : CB · 2024Article
- Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.Current topics in behavioral neurosciences · 2022Review
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.Annual review of neuroscience · 2021Review
- Article
- Refractory density model of cortical direction selectivity: Lagged-nonlagged, transient-sustained, and On-Off thalamic neuron-based mechanisms and intracortical amplification.PLoS computational biology · 2020Article
- Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses.eLife · 2019Article
- Differential tuning of excitation and inhibition shapes direction selectivity in ferret visual cortex.Nature · 2018Article
- Article
- Spatial Asymmetry and Short-Term Suppression Underlie Direction Selectivity of Synaptic Excitation in the Mouse Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Inhibition in Simple Cell Receptive Fields Is Broad and OFF-Subregion Biased.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Spiking Neurons Integrating Visual Stimuli Orientation and Direction Selectivity in a Robotic Context.Frontiers in neurorobotics · 2018Article
- Direction selectivity starts early.Nature neuroscience · 2017Article
- Diversity in Excitation-Inhibition Mismatch Underlies Local Functional Heterogeneity in the Rat Auditory Cortex.Cell reports · 2017Article
- Retinal origin of direction selectivity in the superior colliculus.Nature neuroscience · 2017Article
- Binocular matching of thalamocortical and intracortical circuits in the mouse visual cortex.eLife · 2016Article
- Canonical computations of cerebral cortex.Current opinion in neurobiology · 2016Review
- Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs.Nature neuroscience · 2016Article
- Push-Pull Receptive Field Organization and Synaptic Depression: Mechanisms for Reliably Encoding Naturalistic Stimuli in V1.Frontiers in neural circuits · 2016Article
Corrections and comments
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5 authors.
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Abstract
Direction selectivity (DS) of neuronal responses is fundamental for motion detection. How the integration of synaptic excitation and inhibition contributes to DS however remains not well-understood. Here, in vivo whole-cell voltage-clamp recordings in mouse primary visual cortex (V1) revealed that layer 4 simple cells received direction-tuned excitatory inputs but barely tuned inhibitory inputs under drifting-bar stimulation. Excitation and inhibition exhibited differential temporal offsets under movements of opposite directions: excitation peaked earlier than inhibition at the preferred direction, and vice versa at the null direction. This could be attributed to a small spatial mismatch between overlapping excitatory and inhibitory receptive fields: the distribution of excitatory input strengths was skewed and the skewness was strongly correlated with the DS of excitatory input, whereas that of inhibitory input strengths was spatially symmetric. Neural modeling revealed that the relatively stronger inhibition under null directional movements, as well as the specific spatial-temporal offsets between excitation and inhibition, allowed inhibition to enhance the DS of output responses by suppressing the null response more effectively than the preferred response. Our data demonstrate that while tuned excitatory input provides the basis for DS in mouse V1, the largely untuned and spatiotemporally offset inhibition contributes importantly to sharpening of DS.
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