ArticleComputational mechanics2014
Computational modeling of magnetic nanoparticle targeting to stent surface under high gradient field.
Article in Computational mechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
- Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag-ATMP Translation.Advanced healthcare materials · 2026Review
- Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.Pharmaceutics · 2026Review
- Computational Assessment of Unsteady Flow Effects on Magnetic Nanoparticle Targeting Efficiency in a Magnetic Stented Carotid Bifurcation Artery.Cardiovascular engineering and technology · 2023Article
- Magnetic particle targeting for diagnosis and therapy of lung cancers.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Manipulating nanoparticle transport within blood flow through external forces: an exemplar of mechanics in nanomedicine.Proceedings. Mathematical, physical, and engineering sciences · 2018Review
- Characterization of vascular permeability using a biomimetic microfluidic blood vessel model.Biomicrofluidics · 2017Article
- Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature.Journal of biomechanics · 2017Article
- Pelvic floor dynamics during high-impact athletic activities: A computational modeling study.Clinical biomechanics (Bristol, Avon) · 2017Article
- Thermal therapy with magnetic nanoparticles for cell destruction.Biomedical optics express · 2016Article
- Highly efficient and selective isolation of rare tumor cells using a microfluidic chip with wavy-herringbone micro-patterned surfaces.The Analyst · 2016Article
- Characterization of Nanoparticle Dispersion in Red Blood Cell Suspension by the Lattice Boltzmann-Immersed Boundary Method.Nanomaterials (Basel, Switzerland) · 2016Article
- Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights from Molecular Dynamics Simulation of the Amphotericin B and Nystatin Interactions with Polysorbate 80.Molecules (Basel, Switzerland) · 2015Article
- Cooperative transmembrane penetration of nanoparticles.Scientific reports · 2015Article
- Numerical simulation of particle transport and deposition in the pulmonary vasculature.Journal of biomechanical engineering · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A multi-physics model was developed to study the delivery of magnetic nanoparticles (MNPs) to the stent-implanted region under an external magnetic field. The model is firstly validated by experimental work in literature. Then, effects of external magnetic field strength, magnetic particle size, and flow velocity on MNPs' targeting and binding have been analyzed through a parametric study. Two new dimensionless numbers were introduced to characterize relative effects of Brownian motion (BM), magnetic force induced particle motion, and convective blood flow on MNPs motion. It was found that larger magnetic field strength, bigger MNP size, and slower flow velocity increase the capture efficiency of MNPs. The distribution of captured MNPs on the vessel along axial and azimuthal directions was also discussed. Results showed that the MNPs density decreased exponentially along axial direction after one-dose injection while it was uniform along azimuthal direction in the whole stented region (averaged over all sections). For the beginning section of the stented region, the density ratio distribution of captured MNPs along azimuthal direction is center-symmetrical, corresponding to the center-symmetrical distribution of magnetic force in that section. Two different generation mechanisms are revealed to form four main attraction regions. These results could serve as guidelines to design a better magnetic drug delivery system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.