Evidence map›Paper›PMID 24652914›Full record

ArticleJournal of applied gerontology : the official journal of the Southern Gerontological Society2015

Impact of 6-month aerobic exercise on Alzheimer's symptoms.

Fang Yu, William Thomas, Nathaniel W Nelson, Ulf G Bronas, Maurice Dysken, Jean F Wyman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied gerontology : the official journal of the Southern Gerontological Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Recruitment and Screening Methods in Alzheimer's Disease Research: The FIT-AD Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Determination of Aerobic Capacity via Cycle Ergometer Exercise Testing in Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2017
    Article
  15. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.Annals of clinical and translational neurology · 2014
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fang YuUniversity of Minnesota, Minneapolis, USA yuxxx244@umn.edu.
William ThomasUniversity of Minnesota, Minneapolis, USA.
Nathaniel W NelsonUniversity of St. Thomas, Minneapolis, MN, USA.
Ulf G BronasUniversity of Minnesota, Minneapolis, USA.
Maurice DyskenUniversity of Minnesota, Minneapolis, USA.
Jean F WymanUniversity of Minnesota, Minneapolis, USA.
University of Minnesota · USUniversity of St. Thomas - Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Scholar Development Clinical Research (RMI)K12RR023247 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LUEPKER, RUSSELL V · 2005 to 2009
$13.5M
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NCRR NIH HHS K12 RR023247NCRR NIH HHS K12 RR023247-04
6 · The paper itself

Abstract

Little is known about how aerobic exercise affects Alzheimer's disease (AD). The purpose of this pilot study was to test the impact of 6-month cycling on AD symptoms in community-dwelling older adults with mild-to-moderate AD, using a single-group, repeated-measures design (n = 26). AD symptoms were measured with the AD Assessment Scale-Cognitive (ADAS-Cog), Disability in AD (DAD), and Neuropsychiatric Inventory-Caregiver (NPI-Q) scales at baseline, 3 and 6 months. Data were analyzed using mixed linear models. The ADAS-Cog, DAD, and NPI-Q severity scores remained unchanged over the 6-month period, while caregiver distress decreased 40% (p < .05). We conclude that aerobic exercise may reduce AD symptoms and appears effective in decreasing caregiver distress. Further randomized controlled trials are needed to examine the effects of aerobic exercise in AD.

Indexed as

ExerciseExercise TherapyAgedAged, 80 and overAlzheimer DiseaseCaregiversFemaleHumansLinear ModelsMaleMiddle AgedPilot ProjectsPsychiatric Status Rating ScalesagingAlzheimer’s diseasecognitiondementiaexercise

Identifiers

PMID24652914
PMCPMC5696627
OpenAlexW2120662104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.