ArticleJournal of the American Society of Nephrology : JASN2014
Association of body mass index with outcomes in patients with CKD.
Article in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 279 citations in OpenAlex.
- Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.BMJ (Clinical research ed.) · 2019Pooled it
- Metabolic Syndrome and Psychological Effects of Exercise in Hemodialysis Patients.International journal of environmental research and public health · 2021Trial
- Predictors of Health-Related Quality of Life in Patients with Co-Morbid Diabetes and Chronic Kidney Disease.PloS one · 2016Trial
- Associations Between Body Mass Index and Clinical Outcomes Stratified by Age in Patients Undergoing Maintenance Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Article
- Body roundness index and mortality risk in patients with chronic kidney disease: moving beyond the obesity paradox.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Observational
- Long-term dynamic effect of body mass index on adverse cardiovascular outcomes with targeted maximum likelihood estimation method: result from the KNOW-CKD study.Scientific reports · 2026Article
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- Perinephric fat volume and its negative correlation with the eGFR according to a population health screening: a cross-sectional study.Renal failure · 2025Article
- Body Composition and Kidney Outcomes: A Cohort Study of Rapid Kidney Function Decline and a Mendelian Randomization Analysis of CKD Incidence.Kidney medicine · 2025Article
- Declining Serum Albumin With Stable Body Mass Index: A Mortality Indicator in Predialysis Chronic Kidney Disease.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2025Article
- Risk Factors for Perioperative Urinary Tract Infection After Living Donor Kidney Transplantation Characterized by High Prevalence of Desensitization Therapy: A Single-Center Analysis.Journal of clinical medicine · 2025Article
- Critical Appraisal of "Impact of Bariatric Metabolic Surgery on Cardiovascular, Kidney, and Mortality Outcomes Among Adults with Obesity and Chronic Kidney Disease Across Different Time Frames".Obesity surgery · 2025Article
- Impact of Bariatric Metabolic Surgery on Cardiovascular, Kidney, and Mortality Outcomes Among Adults with Obesity and Chronic Kidney Disease Across Different Time Frames.Obesity surgery · 2025Article
- Risks of All-Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Exploring factors associated with Kidney Disease Quality of Life in patients with advanced chronic kidney disease: the Reach-J CKD cohort study.Clinical and experimental nephrology · 2025Article
- Chronic hepatitis B virus infection increases the risk of kidney disease while antiviral therapy for hepatitis B virus can decrease kidney disease risk.BMC nephrology · 2025Article
- Personalized Nutrition in Chronic Kidney Disease.Biomedicines · 2025Review
- Inflammatory and lipotoxicity mechanisms in obesity related CKD.Frontiers in nephrology · 2025Review
- Association between anthropometric indices and chronic kidney disease: Insights from NHANES 2009-2018.PloS one · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Obesity is associated with higher mortality in the general population, but this association is reversed in patients on dialysis. The nature of the relationship of obesity with adverse clinical outcomes in nondialysis-dependent CKD and the putative interaction of the severity of disease with this association are unclear. We analyzed data from a nationally representative cohort of 453,946 United States veterans with eGFR<60 ml/min per 1.73 m(2). The associations of body mass index categories (<20, 20 to <25, 25 to <30, 30 to <35, 35 to <40, 40 to <45, 45 to <50, and ≥50 kg/m(2)) with all-cause mortality and disease progression (using multiple definitions, including incidence of ESRD, doubling of serum creatinine, and the slopes of eGFR) were examined in Cox proportional hazards models and logistic regression models. Multivariable adjustments were made for age, race, comorbidities and medications, and baseline eGFR. Body mass index showed a relatively consistent U-shaped association with clinical outcomes, with the best outcomes observed in overweight and mildly obese patients. Body mass index levels <25 kg/m(2) were associated with worse outcomes in all patients, independent of severity of CKD. Body mass index levels ≥35 kg/m(2) were associated with worse outcomes in patients with earlier stages of CKD, but this association was attenuated in those patients with eGFR<30 ml/min per 1.73 m(2). Thus, until clinical trials establish the ideal body mass index, a cautious approach to weight management is warranted in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.