ArticleDisease models & mechanisms2014
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model.
Article in Disease models & mechanisms, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Kaempferol activity onPharmaceutical biology · 2026Article
- Azithromycin Mitigates Experimental Cryptosporidiosis-Driven Ileocecal Adenocarcinoma by Modulating Autophagy, Apoptosis, and PI3K/AKT Signaling.Biomedicines · 2026Article
- Deciphering Host-Pathogen Interactions: Role ofPathogens (Basel, Switzerland) · 2025Review
- Article
- Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications.Frontiers in immunology · 2025Review
- Green Synthesis of Chitosan/Silver Nanoparticles UsingPharmaceutics · 2024Article
- Article
- Article
- Role of Cryptosporidium spp in Development of Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Deep glance on the antiparasitic anticancer activities of wheat germ oil in chronically infected immunosuppressed mice with cryptosporidiosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Are Blastocystis hominis and Cryptosporidium spp. playing a positive role in colorectal cancer risk? A systematic review and meta-analysis.Infectious agents and cancer · 2022Review
- IsFood and waterborne parasitology · 2022Article
- DNA methylation alterations caused byFrontiers in cellular and infection microbiology · 2022Review
- PersistentMicroorganisms · 2021Article
- Review
- Cryptosporidium baileyi Pulmonary Infection in Immunocompetent Woman with Benign Neoplasm.Emerging infectious diseases · 2020Article
- Genetic basis for virulence differences of various Cryptosporidium parvum carcinogenic isolates.Scientific reports · 2020Article
- Update on Cryptosporidium spp.: highlights from the Seventh International Giardia and Cryptosporidium Conference.Parasite (Paris, France) · 2020Review
- Prevalence and Genotyping ofJournal of Cancer · 2020Article
- Colorectal cancer and Cryptosporidium spp. infection.PloS one · 2018Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptosporidium species are apicomplexan protozoans that are found worldwide. These parasites constitute a large risk to human and animal health. They cause self-limited diarrhea in immunocompetent hosts and a life-threatening disease in immunocompromised hosts. Interestingly, Cryptosporidium parvum has been related to digestive carcinogenesis in humans. Consistent with a potential tumorigenic role of this parasite, in an original reproducible animal model of chronic cryptosporidiosis based on dexamethasone-treated or untreated adult SCID mice, we formerly reported that C. parvum (strains of animal and human origin) is able to induce digestive adenocarcinoma even in infections induced with very low inoculum. The aim of this study was to further characterize this animal model and to explore metabolic pathways potentially involved in the development of C. parvum-induced ileo-caecal oncogenesis. We searched for alterations in genes or proteins commonly involved in cell cycle, differentiation or cell migration, such as β-catenin, Apc, E-cadherin, Kras and p53. After infection of animals with C. parvum we demonstrated immunohistochemical abnormal localization of Wnt signaling pathway components and p53. Mutations in the selected loci of studied genes were not found after high-throughput sequencing. Furthermore, alterations in the ultrastructure of adherens junctions of the ileo-caecal neoplastic epithelia of C. parvum-infected mice were recorded using transmission electron microscopy. In conclusion, we found for the first time that the Wnt signaling pathway, and particularly the cytoskeleton network, seems to be pivotal for the development of the C. parvum-induced neoplastic process and cell migration of transformed cells. Furthermore, this model is a valuable tool in understanding the host-pathogen interactions associated with the intricate infection process of this parasite, which is able to modulate host cytoskeleton activities and several host-cell biological processes and remains a significant cause of infection worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.