Evidence map›Paper›PMID 24652678›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel.

Aniruddha Roy, Mousumi Bhattacharyya, Mark J Ernsting, Jonathan P May, Shyh-Dar Li

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Interactions of Self-AssembledPharmaceutics · 2019
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aniruddha RoyDrug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Mousumi Bhattacharyya
Mark J Ernsting
Jonathan P May
Shyh-Dar Li
Ontario Institute for Cancer Research · CAUniversity Health Network · CA

Funding

Stromal depletion for pancreatic cancer therapyR21CA176339 · NCI · UNIVERSITY OF BRITISH COLUMBIA · PI FOLTZ, WARREN, HEDLEY, DAVID · 2013 to 2014
$374k
CIHR MSH-130195CIHR PPP-122898NCI NIH HHS CA17633901NCI NIH HHS R21 CA176339
6 · The paper itself

Abstract

unlabelledTaxanes are one of the most potent and broadest spectrum chemotherapeutics used clinically, but also induce significant side effects. Different strategies have been developed to produce a safer taxane formulation. Development of polysaccharide drug conjugates has increased in the recent years because of the demonstrated biocompatibility, biodegradability, safety, and low cost of the biopolymers. This review focuses on polysaccharide-taxane conjugates and provides an overview on various conjugation strategies and their effect on the efficacy. Detailed analyses on the designing factors of an effective polysaccharide-drug conjugate are provided with a discussion on the future direction of this field. For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.

Indexed as

Antineoplastic AgentsChemistry, PharmaceuticalDocetaxelHumansHyaluronic AcidPaclitaxelPolysaccharidesTaxoidsAntineoplastic AgentsDocetaxelHyaluronic AcidPaclitaxelPolysaccharidesTaxoids

Identifiers

PMID24652678
PMCPMC4057951
OpenAlexW1962784809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.