ArticleNeurotoxicity research2014
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
Article in Neurotoxicity research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis.Inflammopharmacology · 2019Trial
- Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume.Translational psychiatry · 2024Article
- How depression and antidepressant drugs affect endocannabinoid system?-review of clinical and preclinical studies.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms.BMC medicine · 2024Article
- Cannabinoid use is enhanced by stress and changes conditioned stress responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Commonalities for comorbidity: Overlapping features of the endocannabinoid system in depression and epilepsy.Frontiers in psychiatry · 2022Review
- Maternal High-Fat Diet ModulatesNutrients · 2021Article
- Peripheral endocannabinoid serum level in association with repetitive transcranial magnetic stimulation (rTMS) treatment in patients with major depressive disorder.Scientific reports · 2021Article
- Endocannabinoids and Precision Medicine for Mood Disorders and Suicide.Frontiers in psychiatry · 2021Article
- Brain structural changes in cannabis dependence: association with MAGL.Molecular psychiatry · 2020Article
- Neurobiological Trajectories Involving Social Isolation in PTSD: A Systematic Review.Brain sciences · 2020Review
- Endocannabinoid System Components as Potential Biomarkers in Psychiatry.Frontiers in psychiatry · 2020Review
- Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study.European archives of psychiatry and clinical neuroscience · 2017Article
- In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.Neuropharmacology · 2017Article
- Changes in the Brain Endocannabinoid System in Rat Models of Depression.Neurotoxicity research · 2017Article
- N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement.Psychopharmacology · 2016Article
- Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?Neurotoxicity research · 2016Review
- High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity.The international journal of neuropsychopharmacology · 2015Review
- The endocannabinoid/endovanilloid system and depression.Current neuropharmacology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endocannabinoid (eCB) system has recently been implicated in both the pathogenesis of depression and the action of antidepressants. Here, we investigated the effect of acutely or chronically administering antidepressants [imipramine (IMI) (15 mg/kg), escitalopram (ESC) (10 mg/kg), and tianeptine (10 mg/kg)] on the levels of both eCBs [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] and N-acylethanolamines (NAEs) [palmitoylethanolamide (PEA) and oleoylethanolamide (OEA)] in various rat brain regions. We also examined the ability of the acute and chronic administration of N-acetylcysteine (NAC) (a mucolytic drug; 100 mg/kg) or URB597 (a fatty acid amide hydrolase inhibitor; 0.3 mg/kg), which have both elicited antidepressant activity in preclinical studies, to affect eCB and NAE levels. Next, we determined whether the observed effects are stable 10 days after the chronic administration of these drugs was halted. We report that the chronic administration of all investigated drugs increased AEA levels in the hippocampus and also increased both AEA and 2-AG levels in the dorsal striatum. NAE levels in limbic regions also increased after treatment with IMI (PEA/OEA), ESC (PEA), and NAC (PEA/OEA). Removing chronic ESC treatment for 10 days affected eCB and NAE levels in the frontal cortex, hippocampus, dorsal striatum, and cerebellum, while a similar tianeptine-free period enhanced accumbal NAE levels. All other drugs maintained their effects after the 10-day washout period. Therefore, the eCB system appears to play a significant role in the mechanism of action of clinically effective and potential antidepressants and may serve as a target for drug design and discovery.
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