Evidence map›Paper›PMID 24652486›Full record

SynthesisJournal of abnormal child psychology2014

Do childhood externalizing disorders predict adult depression? A meta-analysis.

Annemarie K Loth, Deborah A G Drabick, Ellen Leibenluft, Leslie A Hulvershorn

Erratum issuedOpen access · greenAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in Journal of abnormal child psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Evidence Base Update on the Assessment of Irritability, Anger, and Aggression in Youth.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
  4. Article
  5. Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.Journal of child psychology and psychiatry, and allied disciplines · 2026
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  8. Mental health trajectory groups: Family income, neighborhood disadvantage, and role of the school environment.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
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  9. ABA-based teacher training reduces emotional and behavioral problems in Brazilian children.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2026
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Annemarie K LothDepartment of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 705 Riley Hospital Drive, Room 4300, Indianapolis, IN, 46202, USA.
Deborah A G Drabick
Ellen Leibenluft
Leslie A Hulvershorn
Indiana University School of MedicineNational Institutes of Health · USTemple University · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Comorbidity of Conduct Problems and Depressive SymptomsK01MH073717 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI DRABICK, DEBORAH A · 2007 to 2011
$728k
Intramural NIH HHSNIDA NIH HHS K12 DA000357NIMH NIH HHS K01MH0737NIMH NIH HHS K01 MH073717
6 · The paper itself

Abstract

Childhood externalizing disorders have been linked to adult affective disorders, although some studies fail to substantiate this finding. Multiple longitudinal cohort studies identifying childhood psychopathology and their association with adult psychiatric illness have been published. To examine the association between childhood externalizing symptoms or disorders and the development of adult depression across cohorts, a meta-analysis was performed. Potential studies were identified using a PubMed search through November 2013. All published, prospective, longitudinal, community-sampled cohort studies of children (≤ 13 years) with externalizing symptoms or disorders (aggression, conduct problems, oppositional defiant disorder, conduct disorder), reassessed in adulthood (≥ 18 years) for depressive disorders (major depressive disorder, depressive disorder NOS, or dysthymic disorder) were included. A random effects model was used to summarize the pooled effect sizes. Ancillary analyses considered covariates that could account for variance among studies. Ten studies representing eight cohorts of children initially assessed at age 13 or younger (N = 17,712) were included in the meta-analysis. Childhood externalizing behavior was associated with adult depressive disorders (OR = 1.52, 95% confidence interval = 1.27-1.80, p < 0.0001). Utilizing Orwin's Fail-safe N approach, 263 studies with a mean odds ratio of 1.0 would have to be added to the analysis before the cumulative effect would become trivial. Externalizing psychopathology in childhood is associated with the development of unipolar depressive disorders in adulthood.

Indexed as

Internal-External ControlAdultChildDepressive DisorderFemaleHumansLongitudinal StudiesProspective StudiesSocial Behavior Disorders

Identifiers

PMID24652486
PMCPMC4167173
OpenAlexW2083127430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.