ArticleInternational orthopaedics2014
Infectious versus non-infectious loosening of implants: activation of T lymphocytes differentiates between the two entities.
Article in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Ultrasound-stimulated BTO-BSA-gen inhibits implant-associated infections by suppressing bacterial adhesion and potentiating aminoglycosides.Journal of nanobiotechnology · 2026Article
- Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis.Clinical reviews in allergy & immunology · 2025Review
- Osteoimmunology: The Crosstalk between T Cells, B Cells, and Osteoclasts in Rheumatoid Arthritis.International journal of molecular sciences · 2024Review
- A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials.Journal of visualized experiments : JoVE · 2023Article
- Nano wear particles and the periprosthetic microenvironment in aseptic loosening induced osteolysis following joint arthroplasty.Frontiers in cellular and infection microbiology · 2023Review
- Senescent CD4International journal of molecular sciences · 2022Review
- Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena.Aging and disease · 2021Article
- Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-AssociatedFrontiers in immunology · 2021Article
- Biological Reactions to Metal Particles and Ions in the Synovial Layer of Mice.Materials (Basel, Switzerland) · 2020Article
- Graphene Oxide/Copper Nanoderivatives-Modified Chitosan/Hyaluronic Acid Dressings for Facilitating Wound Healing in Infected Full-Thickness Skin Defects.International journal of nanomedicine · 2020Article
- Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment.Journal of clinical medicine · 2019Review
- Chronic Implant-Related Bone Infections-Can Immune Modulation be a Therapeutic Strategy?Frontiers in immunology · 2019Review
- Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms.Materials (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLoosening of implants occurs mainly for two reasons: bacterial infection of the implant or "aseptic loosening" presumably due to wear particles derived from the implant. To gain further insight into the pathomechanism, we analysed activation of the T cell response in these patients.
methodsActivation of peripheral T lymphocytes was determined by cytofluorometry as down-regulation of CD28 and up-regulation of CD11b. In addition, tissue samples obtained during surgery were analysed by quantitative RT-PCR for gene expression of CD3, CD14 and cathepsin K, as markers for T cells, monocytes/macrophages or osteoclasts, respectively.
resultsActivated T lymphocytes were detected in patients with infection but not in patients with aseptic loosening. Gene expression of CD3 was significantly enhanced in tissues of patients with infection compared to those with aseptic loosening. Expression of CD14 and of cathepsin K did not differ between the two groups.
conclusionImplant-associated infection and aseptic loosening are associated with a local inflammatory response, which eventually results in osteoclastogenesis and bone resorption. Systemic T cell activation, in contrast, occurs only in patients with implant-associated infection, and hence analysis of T cell activation markers could serve as a diagnostic tool to differentiate between the two entities.
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