ReviewCurrent cardiology reports2014
CFR and FFR assessment with PET and CTA: strengths and limitations.
Review in Current cardiology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis.Rheumatology international · 2018Pooled it
- Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study.International journal of cardiology · 2019Trial
- Comparative diagnostic performance and stability of deep learning- and CFD-based CT-FFR across vessels, cardiac phases, and centers.Frontiers in cardiovascular medicine · 2026Article
- Multimodal Imaging in MI with Non-obstructive Coronary Arteries: Unraveling Pathophysiology and Guiding Management.US cardiology · 2026Review
- Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA).Journal of the Society for Cardiovascular Angiography & Interventions · 2024Review
- Evolving Diagnostic and Management Advances in Coronary Heart Disease.Life (Basel, Switzerland) · 2023Review
- Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers.Scientific reports · 2021Article
- Effect of Patient-Specific Coronary Flow Reserve Values on the Accuracy of MRI-Based Virtual Fractional Flow Reserve.Frontiers in cardiovascular medicine · 2021Article
- Software reproducibility of myocardial blood flow and flow reserve quantification in ischemic heart disease: AJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease.Journal of cardiovascular translational research · 2020Review
- Automatic Estimation of Coronary Blood Flow Velocity Step 1 for Developing a Tool to Diagnose Patients With Micro-Vascular Angina Pectoris.Frontiers in cardiovascular medicine · 2019Article
- Fractional Flow Reserve or Coronary Flow Reserve for the Assessment of Myocardial Perfusion : Implications of FFR as an Imperfect Reference Standard for Myocardial Ischemia.Current cardiology reports · 2018Review
- SPECT myocardial blood flow quantitation toward clinical use: a comparative study withEuropean journal of nuclear medicine and molecular imaging · 2017Article
- How to Utilize Coronary Computed Tomography Angiography in the Treatment of Coronary Artery Disease.Journal of cardiovascular ultrasound · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Positron emission tomography (PET) myocardial perfusion imaging (MPI) has high diagnostic accuracy and prognostic value. PET-MPI can also be used to quantitatively evaluate regional myocardial blood flow (MBF). This technique also allows the calculation of the coronary flow reserve (CFR)/myocardial flow reserve (MFR), which is the ratio of MBF at peak hyperemia to resting MBF. Coronary computed tomography angiography (CTA) is a non-invasive method for accurate detection and exclusion of high-grade coronary stenoses, when compared to an invasive coronary angiography reference standard. However, CTA assessment of coronary stenoses tends toward overestimation, and CTA cannot determine physiologic significance of lesions. Recent advances in computational fluid dynamics and image-based modeling permit calculation of non-invasive fractional flow reserve derived from CT (FFRCT), without the need for additional imaging, modification of acquisition protocols, or administration of medications. In this review, we cover the CFR/MFR assessment by PET and FFR assessment by CT.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.