Trial reportStroke2014
Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation.
Trial report in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 93 citations in OpenAlex.
- Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke: A Randomized Clinical Trial.JAMA neurology · 2025Trial
- A randomized trial of Trendelenburg position for acute moderate ischemic stroke.Nature communications · 2023Trial
- Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Trial
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy.Intensive care medicine experimental · 2025Article
- Microvascular reperfusion during endovascular therapy: the balance of supply and demand.Journal of neurointerventional surgery · 2024Article
- Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification.Neurocritical care · 2024Review
- Article
- A systematic review on the assessment of cerebral autoregulation in patients with Large Vessel Occlusion.Frontiers in neurology · 2023Review
- International beliefs and head positioning practices in patients with spontaneous hyperacute intracerebral hemorrhage.Therapeutic advances in neurological disorders · 2023Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit.Biomedical optics express · 2022Article
- Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy.IEEE access : practical innovations, open solutions · 2022Article
- Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients.Frontiers in neurology · 2022Article
- Effects of Systemic Physiology on Mapping Resting-State Networks Using Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2022Article
- Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report.Brain sciences · 2021Article
- The association between early impairment in cerebral autoregulation and outcome in a pediatric swine model of cardiac arrest.Resuscitation plus · 2020Article
- The Effects of Gradual Change in Head Positioning on the Relationship between Systemic and Cerebral Haemodynamic Parameters in Healthy Controls and Acute Ischaemic Stroke Patients.Brain sciences · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeA primary goal of acute ischemic stroke (AIS) management is to maximize perfusion in the affected region and surrounding ischemic penumbra. However, interventions to maximize perfusion, such as flat head-of-bed (HOB) positioning, are currently prescribed empirically. Bedside monitoring of cerebral blood flow (CBF) allows the effects of interventions such as flat HOB to be monitored and may ultimately be used to guide clinical management.
methodsCerebral perfusion was measured during HOB manipulations in 17 patients with unilateral AIS affecting large cortical territories in the anterior circulation. Simultaneous measurements of frontal CBF and arterial flow velocity were performed with diffuse correlation spectroscopy and transcranial Doppler ultrasound, respectively. Results were analyzed in the context of available clinical data and a previous study.
resultsFrontal CBF, averaged over the patient cohort, decreased by 17% (P=0.034) and 15% (P=0.011) in the ipsilesional and contralesional hemispheres, respectively, when HOB was changed from flat to 30°. Significant (cohort-averaged) changes in blood velocity were not observed. Individually, varying responses to HOB manipulation were observed, including paradoxical increases in CBF with increasing HOB angle. Clinical features, stroke volume, and distance to the optical probe could not explain this paradoxical response.
conclusionsA lower HOB angle results in an increase in cortical CBF without a significant change in arterial flow velocity in AIS, but there is variability across patients in this response. Bedside CBF monitoring with diffuse correlation spectroscopy provides a potential means to individualize interventions designed to optimize CBF in AIS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.