ReviewIndian journal of pediatrics2014
Pathophysiology and current management of necrotizing enterocolitis.
Review in Indian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04344639 (Incidence, Risk Factors, Severity and Prognosis of Necrotizing Enterocolitis in Turkey), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence, Risk Factors, Severity and Prognosis of Necrotizing Enterocolitis in Turkey: A Prospective Multicentre Study
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.Italian journal of pediatrics · 2025Pooled it
- To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Necrotizing enterocolitis in very preterm infants: an epidemiological study in Jiangsu, China.Frontiers in pediatrics · 2026Article
- Twins and Necrotizing Enterocolitis: Genetic Relevance.Current pediatric reviews · 2026Review
- Outcomes of primary intestinal anastomosis versus stoma in necrotizing enterocolitis: A systematic review and meta-analysis.Surgery in practice and science · 2025Review
- Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders.Stem cells translational medicine · 2025Review
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles attenuate experimental necrotizing enterocolitis.Stem cell research & therapy · 2025Article
- Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates.Frontiers in pediatrics · 2025Article
- Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Association of Surgical Necrotizing Enterocolitis and Its Timing with Retinopathy of Prematurity.American journal of perinatology · 2023Article
- Galectin-4 as a Novel Biomarker of Neonatal Intestinal Injury.Digestive diseases and sciences · 2022Article
- Role of platelets in neonatal necrotizing enterocolitis.Pediatric research · 2021Review
- Application of abdominal sonography in diagnosis of infants with necrotizing enterocolitis.Medicine · 2019Article
- Comparison of abdominal radiographs and sonography in prognostic prediction of infants with necrotizing enterocolitis.Pediatric surgery international · 2018Article
- ProbioticJournal of probiotics & health · 2017Article
- Advantages of abdominal ultrasound in the management of infants with necrotizing enterocolitis.Pediatric surgery international · 2017Article
- Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis.Pediatric research · 2017Article
- Systemic changes and adverse effects induced by retinopathy of prematurity screening.International journal of ophthalmology · 2016Article
- Prospective evaluation of the impact of sonography on the management and surgical intervention of neonates with necrotizing enterocolitis.Pediatric surgery international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of morbidity and mortality in these infants. In this article, the authors review the pathophysiology and clinical presentation of NEC and provide a critical appraisal of the evidence supporting various prophylactic and therapeutic strategies. A literature search was performed using the databases PubMed, EMBASE, and Scopus. Current pathophysiological models of NEC suggest that the disease occurs when mucosal injury in the preterm intestine results in translocation of luminal bacteria across the epithelial barrier, triggering an exaggerated and damaging local inflammatory response. Medical management of NEC is largely supportive and likely does not modify the etiopathogenesis of this disease. Antenatal steroids, human milk feedings, adoption of standardized feeding regimens, and probiotics hold promise for prevention of NEC. Future research should focus on early recognition that occurs well before the onset of intestinal necrosis, and prevention of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.