Evidence map›Paper›PMID 24651884›Full record

Observational studyIntensive care medicine2014

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study.

Pascale Le Maguet, Antoine Roquilly, Sigismond Lasocki, Karim Asehnoune, Elsa Carise, Marjorie Saint Martin, Olivier Mimoz, Grégoire Le Gac, Dominique Somme, Catherine Cattenoz and 3 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03913299 (Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery "Frail Heart" Study.), which is not on this map. Cited by 124 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03913299 active not recruitingnot on this mapstarted 2019, after this paper: background citation

Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery "Frail Heart" Study.

Typeobservational_patient_registrySponsorCliniques universitaires Saint-Luc- Université Catholique de LouvainRan2019 to 2026Enrolled2,080ConditionsFrail Elderly Syndrome, Frailty, Surgery
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  7. Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools.JBI database of systematic reviews and implementation reports · 2017
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Pascale Le MaguetDépartement d'Anesthésie Réanimation, CHU Rennes, Rennes, France.
Antoine Roquilly
Sigismond Lasocki
Karim Asehnoune
Elsa Carise
Marjorie Saint Martin
Olivier Mimoz
Grégoire Le Gac
Dominique Somme
Catherine Cattenoz
Fanny Feuillet
Yannick Malledant
Philippe Seguin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFrailty is a recent concept used for evaluating elderly individuals. Our study determined the prevalence of frailty in intensive care unit (ICU) patients and its impact on the rate of mortality.

methodsA multicenter, prospective, observational study performed in four ICUs in France included 196 patients aged ≥65 years hospitalized for >24 h during a 6-month study period. Frailty was determined using the frailty phenotype (FP) and the clinical frailty score (CFS). The patients were separated as follows: FP score <3 or ≥3 and CFS <5 or ≥5.

resultsFrailty was observed in 41 and 23% of patients on the basis of an FP score ≥3 and a CFS ≥5, respectively. At admission to the ICU, the Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores did not differ between the frail and nonfrail patients. In the multivariate analysis, the risk factors for ICU mortality were FP score ≥3 [hazard ratio (HR), 3.3; 95% confidence interval (CI), 1.6-6.6; p < 0.001], male gender (HR, 2.4; 95% CI, 1.1-5.3; p = 0.026), cardiac arrest before admission (HR, 2.8; 95% CI, 1.1-7.4; p = 0.036), SAPS II score ≥46 (HR, 2.6; 95% CI, 1.2-5.3; p = 0.011), and brain injury before admission (HR, 3.5; 95% CI, 1.6-7.7; p = 0.002). The risk factors for 6-month mortality were a CFS ≥5 (HR, 2.4; 95% CI, 1.49-3.87; p < 0.001) and a SOFA score ≥7 (HR, 2.2; 95% CI, 1.35-3.64; p = 0.002). An increased CFS was associated with significant incremental hospital and 6-month mortalities.

conclusionsFrailty is a frequent occurrence and is independently associated with increased ICU and 6-month mortalities. Notably, the CFS predicts outcomes more effectively than the commonly used ICU illness scores.

Indexed as

Hospital MortalityOrgan Dysfunction ScoresSeverity of Illness IndexActivities of Daily LivingAgedAPACHEComorbidityFemaleFrail ElderlyFranceHumansIntensive Care UnitsKaplan-Meier EstimateMaleMemory DisordersMultivariate Analysis

Identifiers

PMID24651884

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.