ArticleAJNR. American journal of neuroradiology2014
Generalized versus patient-specific inflow boundary conditions in computational fluid dynamics simulations of cerebral aneurysmal hemodynamics.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Letter to the Editor: Correlation between computational fluid dynamics-derived low wall shear stress and vessel wall enhancement on high-resolution MR vessel wall imaging in intracranial aneurysms.European radiology · 2026Article
- Computational Fluid Dynamics Approaches for Analyzing Rupture and Growth of Intracranial Aneurysms: A Systematic Review.Biomedicines · 2025Review
- Role of patient-specific blood properties in computational fluid dynamics simulation of flow diverter deployed cerebral aneurysms.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- Identification of intra-individual variation in intracranial arterial flow by MRI and the effect on computed hemodynamic descriptors.Magma (New York, N.Y.) · 2021Article
- Hemodynamic Data Assimilation in a Subject-specific Circle of Willis Geometry.Clinical neuroradiology · 2021Article
- Analysis of Morphological-Hemodynamic Risk Factors for Aneurysm Rupture Including a Newly Introduced Total Volume Ratio.Journal of personalized medicine · 2021Article
- Prediction of Cerebral Aneurysm Hemodynamics With Porous-Medium Models of Flow-Diverting Stents via Deep Learning.Frontiers in physiology · 2021Article
- Discrimination of intracranial aneurysm rupture status: patient-specific inflow boundary may not be a must-have condition in hemodynamic simulations.Neuroradiology · 2020Article
- A Hemodynamic Mechanism Correlating with the Initiation of MCA Bifurcation Aneurysms.AJNR. American journal of neuroradiology · 2020Article
- Comparing Morphology and Hemodynamics of Stable-versus-Growing and Grown Intracranial Aneurysms.AJNR. American journal of neuroradiology · 2019Article
- Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.Annals of biomedical engineering · 2019Article
- Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery.AJNR. American journal of neuroradiology · 2019Article
- Differences in Cerebral Aneurysm Rupture Rate According to Arterial Anatomies Depend on the Hemodynamic Environment.AJNR. American journal of neuroradiology · 2019Observational
- Patient-Specific Computational Fluid Dynamics in Ruptured Posterior Communicating Aneurysms Using Measured Non-Newtonian Viscosity : A Preliminary Study.Journal of Korean Neurosurgical Society · 2019Article
- A non-dimensional parameter for classification of the flow in intracranial aneurysms. II. Patient-specific geometries.Physics of fluids (Woodbury, N.Y. : 1994) · 2019Article
- Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge.Cardiovascular engineering and technology · 2018Article
- Wall Shear Stress and Flow Patterns in Unruptured and Ruptured Anterior Communicating Artery Aneurysms Using Computational Fluid Dynamics.Journal of Korean Neurosurgical Society · 2018Article
- Prediction of rupture risk in anterior communicating artery aneurysms with a feed-forward artificial neural network.European radiology · 2018Article
- Aneurysmal Parent Artery-Specific Inflow Conditions for Complete and Incomplete Circle of Willis Configurations.AJNR. American journal of neuroradiology · 2018Article
- Better Than Nothing: A Rational Approach for Minimizing the Impact of Outflow Strategy on Cerebrovascular Simulations.AJNR. American journal of neuroradiology · 2018Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAttempts have been made to associate intracranial aneurysmal hemodynamics with aneurysm growth and rupture status. Hemodynamics in aneurysms is traditionally determined with computational fluid dynamics by using generalized inflow boundary conditions in a parent artery. Recently, patient-specific inflow boundary conditions are being implemented more frequently. Our purpose was to compare intracranial aneurysm hemodynamics based on generalized versus patient-specific inflow boundary conditions. MATERIALS AND
methodsFor 36 patients, geometric models of aneurysms were determined by using 3D rotational angiography. 2D phase-contrast MR imaging velocity measurements of the parent artery were performed. Computational fluid dynamics simulations were performed twice: once by using patient-specific phase-contrast MR imaging velocity profiles and once by using generalized Womersley profiles as inflow boundary conditions. Resulting mean and maximum wall shear stress and oscillatory shear index values were analyzed, and hemodynamic characteristics were qualitatively compared.
resultsQuantitative analysis showed statistically significant differences for mean and maximum wall shear stress values between both inflow boundary conditions (P < .001). Qualitative assessment of hemodynamic characteristics showed differences in 21 cases: high wall shear stress location (n = 8), deflection location (n = 3), lobulation wall shear stress (n = 12), and/or vortex and inflow jet stability (n = 9). The latter showed more instability for the generalized inflow boundary conditions in 7 of 9 patients.
conclusionsUsing generalized and patient-specific inflow boundary conditions for computational fluid dynamics results in different wall shear stress magnitudes and hemodynamic characteristics. Generalized inflow boundary conditions result in more vortices and inflow jet instabilities. This study emphasizes the necessity of patient-specific inflow boundary conditions for calculation of hemodynamics in cerebral aneurysms by using computational fluid dynamics techniques.
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