ArticleJournal of computer assisted tomography
Effect of pre-enhancement set point on computed tomographic perfusion values in normal liver and metastases to the liver from neuroendocrine tumors.
Article in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A physiologically based pharmacokinetic model for [EJNMMI research · 2023Article
- Radiographic characteristics of neuroendocrine liver metastases do not predict clinical outcomes following liver resection.Hepatobiliary surgery and nutrition · 2020Article
- Liver CT perfusion: which is the relevant delay that reduces radiation dose and maintains diagnostic accuracy?European radiology · 2019Article
- Inferring Stable Acquisition Durations for Applications of Perfusion Imaging in Oncology.Cancer informatics · 2015Article
- CT Perfusion Characteristics Identify Metastatic Sites in Liver.BioMed research international · 2015Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe objective of this study was to assess the effects of pre-enhancement set point (T1) positioning on computed tomographic perfusion (CTp) parameter values.
methodsThe CTp data from 16 patients with neuroendocrine liver metastases were analyzed with distributed parameter modeling to yield tissue blood flow (BF), blood volume, mean transit time, permeability, and hepatic arterial fraction for tumor and normal liver, with displacements in T1 of ±0.5, ±1.0, ±2.0 seconds, relative to the reference standard. A linear mixed-effects model was used to assess the displacement effects.
resultsEffects on the CTp parameter values were variable: BF was not significantly affected, but T1 positions of ≥+1.0 second and -2.0 seconds or longer significantly affected the other CTp parameters (P ≤ 0.004). Mean differences in the CTp parameter values versus the reference standard for BF, blood volume, mean transit time, permeability, and hepatic arterial fraction ranged from -5.0% to 5.2%, -12.7% to 8.9%, -12.5% to 8.1%, -5.3% to 5.7%, and -12.9% to 26.0%, respectively.
conclusionsCTp parameter values can be significantly affected by T1 positioning.
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