Evidence map›Paper›PMID 24651672›Full record

ReviewCancer biology & therapy2014

Melanoma immunotherapy.

Martina Sanlorenzo, Igor Vujic, Christian Posch, Akshay Dajee, Adam Yen, Sarasa Kim, Michelle Ashworth, Michael D Rosenblum, Alain Algazi, Simona Osella-Abate and 3 more

Abstract readReview
In one paragraph

Review in Cancer biology & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  4. Review
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  9. Article
  10. Impact of [Diagnostics (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Martina SanlorenzoUniversity of California San Francisco; San Francisco, CA USA; Department of Medical Sciences; Section of Dermatology; University of Turin; Turin, Italy.
Igor VujicUniversity of California San Francisco; San Francisco, CA USA; The Rudolfstiftung Hospital; Vienna, Austria.
Christian PoschUniversity of California San Francisco; San Francisco, CA USA; The Rudolfstiftung Hospital; Vienna, Austria.
Akshay DajeeUniversity of California San Francisco; San Francisco, CA USA.
Adam YenUniversity of California San Francisco; San Francisco, CA USA.
Sarasa KimUniversity of California San Francisco; San Francisco, CA USA.
Michelle AshworthUniversity of California San Francisco; San Francisco, CA USA.
Michael D RosenblumUniversity of California San Francisco; San Francisco, CA USA.
Alain AlgaziUniversity of California San Francisco; San Francisco, CA USA.
Simona Osella-AbateDepartment of Medical Sciences; Section of Dermatology; University of Turin; Turin, Italy.
Pietro QuaglinoDepartment of Medical Sciences; Section of Dermatology; University of Turin; Turin, Italy.
Adil DaudUniversity of California San Francisco; San Francisco, CA USA.
Susanna Ortiz-UrdaUniversity of California San Francisco; San Francisco, CA USA.

Funding

Role of KIT in Early Melanoma DevelopmentK08CA155035 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ORTIZ URDA, SUSANA · 2011 to 2015
$610k
NCI NIH HHS K08 CA155035
6 · The paper itself

Abstract

Immunotherapy is a cornerstone in the treatment of melanoma, and is intended to modulate the host immunity against the tumor. Immunotherapy can be used in an adjuvant setting, after complete surgical excision in patients with a high risk of disease relapse and as a treatment in advanced (unresectable or metastatic) stages. Development of novel therapeutic approaches and the optimization of existing therapies hold a great promise in the field of melanoma therapy research. Different clinical trials are ongoing, and immunotherapy is showing the ability to confirm durable clinical benefits in selected groups of melanoma patients. The aim of this review is to summarize different types of immunotherapy agents, as well as to discuss different strategies, complementary regimens, and possible biomarkers of response to the treatment.

Indexed as

Immunotherapy, ActiveImmunotherapy, AdoptiveAntibodies, MonoclonalAntineoplastic AgentsBiomarkers, TumorHumansImmunologic FactorsMelanomaAntibodies, MonoclonalAntineoplastic AgentsBiomarkers, TumorImmunologic Factorsanti-PD-1CTLA-4immunoprofilinginterferonsinterleukinsipilimumabPD-1

Identifiers

PMID24651672
PMCPMC4049781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.