ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2014
Oncogenic viral prevalence in invasive vulvar cancer specimens from human immunodeficiency virus-positive and -negative women in Botswana.
Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Clinico-pathological and treatment characteristics of HIV and non-HIV related vulvar cancers: Analysis of a South African cohort.PloS one · 2025Article
- High-risk human papillomavirus-associated vulvar neoplasia among women living with human immunodeficiency virus in Zambia.African journal of laboratory medicine · 2022Article
- Vulvar cancer in Botswana in women with and without HIV infection: patterns of treatment and survival outcomes.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2021Observational
- Human papillomavirus genotypes in cervical and other HPV-related anogenital cancer in Rwanda, according to HIV status.International journal of cancer · 2020Article
- Genital Kaposi sarcoma in a HIV and syphilis co-infected patient: case presentation.BMC infectious diseases · 2019Article
- A case-control study of HIV infection and cancer in the era of antiretroviral therapy in Rwanda.International journal of cancer · 2018Article
- Cancer in Kenya: types and infection-attributable. Data from the adult population of two National referral hospitals (2008-2012).AAS open research · 2018Article
- The burden of HPV associated cancers in two regions in Nigeria 2012-2014.Cancer epidemiology · 2016Article
- Burden of Cancers Attributable to Infectious Agents in Nigeria: 2012-2014.Frontiers in oncology · 2016Article
- Burkitt lymphoma research in East Africa: highlights from the 9(th) African organization for research and training in cancer conference held in Durban, South Africa in 2013.Infectious agents and cancer · 2014Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveThe primary aim of this study was to describe the prevalence of select oncogenic viruses within vulvar squamous cell carcinoma (VSCC) and their association with human immunodeficiency virus (HIV) status in women in Botswana, where the national HIV prevalence is the third highest in the world.
methodsA cross-sectional study of biopsy-confirmed VSCC specimens and corresponding clinical data was conducted in Gaborone, Botswana. Polymerase chain reaction (PCR) and immunohistochemistry (IHC) viral testing were done for Epstein-Barr virus, human papillomavirus (HPV) strains, and Kaposi sarcoma herpesvirus, and PCR viral testing alone was done for John Cunningham virus.
resultsHuman papillomavirus prevalence by PCR was 100% (35/35) among tested samples. Human papillomavirus type 16 was the most prevalent HPV strain (82.9% by PCR, 94.7% by either PCR or IHC). Kaposi sarcoma herpesvirus prevalence by PCR had a significant association with HIV status (P = 0.013), but not by IHC (P = 0.650).
conclusionsThe high burden of HPV, specifically HPV16, in vulvar squamous cell cancer in Botswana suggests a distinct HPV profile that differs from other studied populations, which provides increased motivation for HPV vaccination efforts. Oncogenic viruses Kaposi sarcoma herpesvirus and Epstein-Barr virus were also more prevalent in our study population, although their potential role in vulvar squamous cell cancer pathology is unclear.
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