ArticleGenetics in medicine : official journal of the American College of Medical Genetics2014
Comparing universal Lynch syndrome tumor-screening programs to evaluate associations between implementation strategies and patient follow-through.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- A systematic review of the use of the Consolidated Framework for Implementation Research.Implementation science : IS · 2016Pooled it
- A WeChat-Based Decision Aid Intervention to Promote Informed Decision-Making for Family Members Regarding the Genetic Testing of Patients With Colorectal Cancer: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- From theory to practice: improving Lynch syndrome recognition through evidence-based education.Familial cancer · 2026Review
- Impact of COVID-19 on Universal Tumor Screening, Referral Rates and Attendance at Cancer Genetic Counseling at a Safety-Net University Hospital.Current oncology (Toronto, Ont.) · 2025Article
- Increased colorectal and endometrial cancer rates in a genomically ascertained Lynch syndrome cohort.JNCI cancer spectrum · 2025Article
- A guide to utilizing implementation science for genetic counseling.Journal of genetic counseling · 2025Article
- Mixed-method evaluation of the Fairer Futures Fund: a £22.2 m public health initiative designed to reduce health inequalities in Birmingham and Solihull (UK).Frontiers in public health · 2025Article
- One-Stop Colon and Endometrial Screening (ONCE): a prospective study of combined cancer screening for Lynch syndrome.Proceedings (Baylor University. Medical Center) · 2025Article
- Universal screening of colorectal tumors for lynch syndrome: a survey of patient experiences and opinions.Hereditary cancer in clinical practice · 2024Article
- Comparison of immediate germline sequencing and multi-step screening for Lynch syndrome detection in high-risk endometrial and colorectal cancer patients.Journal of gynecologic oncology · 2024Article
- Physician perspective on the implementation of risk mitigation strategies when prescribing opioid medications: a qualitative analysis.BMC health services research · 2023Article
- Using a multistep approach with multidisciplinary team to increase the diagnosis rate of Lynch syndrome-associated colorectal cancer after universal screening: a single-center study in Japan.Hereditary cancer in clinical practice · 2023Article
- A picture is worth a thousand words: advancing the use of visualization tools in implementation science through process mapping and matrix heat mapping.Implementation science communications · 2023Article
- Rural barriers and facilitators of lung cancer screening program implementation in the veterans health administration: a qualitative study.Frontiers in health services · 2023Article
- Prenatal oral health guidelines: a theory- and practice-informed approach to survey development using a modified-Delphi technique and cognitive interviews.Implementation science communications · 2022Article
- Economic Evaluation of Universal Lynch Syndrome Screening Protocols among Newly Diagnosed Patients with Colorectal Cancer.Journal of personalized medicine · 2021Article
- Stakeholders' views of integrating universal tumour screening and genetic testing for colorectal and endometrial cancer into routine oncology.European journal of human genetics : EJHG · 2021Article
- Article
- Protocol to evaluate an enterprise-wide initiative to increase access to lung cancer screening in the Veterans Health Administration.Clinical imaging · 2021Article
- Implementing PROMs in routine clinical care: a qualitative exploration of GP perspectives.BJGP open · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeUniversal tumor screening (UTS) for all colorectal cancer patients can improve the identification of Lynch syndrome, the most common cause of hereditary colorectal cancer. This multiple-case study explored how variability in UTS procedures influenced patient follow-through (PF) with germ-line testing after a screen-positive result.
methodsData were obtained through Web-based surveys and telephone interviews with institutional informants. Institutions were categorized as Low-PF (≤10% underwent germ-line testing), Medium-PF (11-40%), or High-PF (>40%). To identify implementation procedures (i.e., conditions) unique to High-PF institutions, qualitative comparative analysis was performed.
resultsTwenty-one informants from 15 institutions completed surveys and/or interviews. Conditions present among all five High-PF institutions included the following: (i) disclosure of screen-positive results to patients by genetic counselors; and (ii) genetic counselors either facilitate physician referrals to genetics professionals or eliminate the need for referrals. Although both of these High-PF conditions were present among two Medium-PF institutions, automatic reflex testing was lacking and difficulty contacting screen-positive patients was a barrier. The three remaining Medium-PF and five Low-PF institutions lacked the conditions found in High-PF institutions.
conclusionMETHODS for streamlining UTS procedures, incorporating a high level of involvement of genetic counselors in tracking and communication of results and in reducing barriers to patient contact, are reviewed within a broader discussion on maximizing the effectiveness and public health impact of UTS.
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Registered trials
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