Evidence map›Paper›PMID 24651517›Full record

ArticleJournal of cardiovascular pharmacology and therapeutics2014

Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine.

Carol Y Suh, Zelun Wang, Oscar Bártulos, Yibing Qyang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular pharmacology and therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carol Y SuhDepartment of Genetics, Yale University, New Haven, CT, USA Department of Internal Medicine, Section of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, CT, USA Yale Stem Cell Center, Yale University, New Haven, CT, USA.
Zelun WangDepartment of Internal Medicine, Section of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Oscar BártulosDepartment of Internal Medicine, Section of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, CT, USA Yale Stem Cell Center, Yale University, New Haven, CT, USA.
Yibing QyangDepartment of Internal Medicine, Section of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, CT, USA Yale Stem Cell Center, Yale University, New Haven, CT, USA Department of Pathology, Yale University, New Haven, CT, USA yibing.qyang@yale.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI ANN M HABERMAN · 1985 to 2026
$85.0M
Human tissue-engineered blood vessels using induced pluripotent stem cellsR01HL116705 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2013 to 2017
$2.0M
Derivation of Heart Cells from Human Embryonic and Induced Pluripotent Stem CellsK02HL101990 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2010 to 2014
$489k
NHLBI NIH HHS K02 HL101990NHLBI NIH HHS R01 HL116705
6 · The paper itself

Abstract

Cardiovascular diseases remain the leading causes of morbidity and mortality in the developed world. Cellular-based cardiac regenerative therapy serves as a potential approach to treating cardiovascular diseases. Although various cellular types have been tested, induced pluripotent stem cells (iPSCs) are regarded as a promising cell source for therapy. In this review, we will highlight some of the advances in generating iPSCs and differentiation to cardiac cells. We will also discuss the progress in modeling cardiovascular diseases using iPSCs-derived cardiac cells. As we continue to make progress in iPSC and cardiac differentiation technology, we will come closer to the application of cardiac regenerative medicine.

Indexed as

cardiac differentiationdisease modelinginduced pluripotent stem cell

Identifiers

PMID24651517
PMCPMC4169350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.