ArticleNature chemistry2014
The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster.
Article in Nature chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hydrogen-Producing Catalysts Based on Ferredoxin Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]-Hydrogenase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Facile Functionalization of Carbon Electrodes for Efficient Electroenzymatic Hydrogen Production.JACS Au · 2023Article
- Electrochemical control of [FeFe]-hydrogenase single crystals reveals complex redox populations at the catalytic site.Dalton transactions (Cambridge, England : 2003) · 2021Article
- Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture.Chemical science · 2020Article
- The roles of long-range proton-coupled electron transfer in the directionality and efficiency of [FeFe]-hydrogenases.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Suppressing hydrogen peroxide generation to achieve oxygen-insensitivity of a [NiFe] hydrogenase in redox active films.Nature communications · 2020Article
- Electrochemical Characterization of a Complex FeFe Hydrogenase, the Electron-Bifurcating Hnd FromFrontiers in chemistry · 2020Article
- How [FeFe]-Hydrogenase Facilitates Bidirectional Proton Transfer.Journal of the American Chemical Society · 2019Article
- The final steps of [FeFe]-hydrogenase maturation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Viologen-modified electrodes for protection of hydrogenases from high potential inactivation while performing HDalton transactions (Cambridge, England : 2003) · 2018Article
- Spectroscopical Investigations on the Redox Chemistry of [FeFe]-Hydrogenases in the Presence of Carbon Monoxide.Molecules (Basel, Switzerland) · 2018Article
- Mechanism of ONature chemistry · 2017Article
- Characterization of [FeFe] Hydrogenase O2 Sensitivity Using a New, Physiological Approach.The Journal of biological chemistry · 2016Article
- Stepwise isotope editing of [FeFe]-hydrogenases exposes cofactor dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.Chemical science · 2016Article
- Lyophilization protects [FeFe]-hydrogenases against O2-induced H-cluster degradation.Scientific reports · 2015Article
- [FeFe]-hydrogenase abundance and diversity along a vertical redox gradient in Great Salt Lake, USA.International journal of molecular sciences · 2014Article
- A redox hydrogel protects hydrogenase from high-potential deactivation and oxygen damage.Nature chemistry · 2014Article
- Borane-protected cyanides as surrogates of H-bonded cyanides in [FeFe]-hydrogenase active site models.Inorganic chemistry · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature is a valuable source of inspiration in the design of catalysts, and various approaches are used to elucidate the mechanism of hydrogenases, the enzymes that oxidize or produce H2. In FeFe hydrogenases, H2 oxidation occurs at the H-cluster, and catalysis involves H2 binding on the vacant coordination site of an iron centre. Here, we show that the reversible oxidative inactivation of this enzyme results from the binding of H2 to coordination positions that are normally blocked by intrinsic CO ligands. This flexibility of the coordination sphere around the reactive iron centre confers on the enzyme the ability to avoid harmful reactions under oxidizing conditions, including exposure to O2. The versatile chemistry of the diiron cluster in the natural system might inspire the design of novel synthetic catalysts for H2 oxidation.
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