ArticlePloS one2014
Organization of lipids in the tear film: a molecular-level view.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Meibomian Gland Shortening Is Associated With Altered Meibum Composition.Investigative ophthalmology & visual science · 2024Article
- Nonpolar Lipids Contribute to Midday Fogging During Scleral Lens Wear.Investigative ophthalmology & visual science · 2023Article
- Effects of a New Formulation of Multiple-Action Tear Substitute on Objective Ocular Surface Parameters and Ocular Discomfort Symptoms in Patients with Dry Eye Disease.Ophthalmology and therapy · 2022Article
- The Potential Role of SP-G as Surface Tension Regulator in Tear Film: From Molecular Simulations to Experimental Observations.International journal of molecular sciences · 2022Article
- Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure.The ocular surface · 2022Article
- Effect of ocular demodicosis on the stability of the tear film and the tear break up time.Scientific reports · 2021Article
- Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease.Investigative ophthalmology & visual science · 2021Article
- Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction.The ocular surface · 2021Article
- Lipocalin-1 is the acceptor protein for phospholipid transfer protein in tears.Biochemical and biophysical research communications · 2021Article
- Tear Lipocalin and Lipocalin-Interacting Membrane Receptor.Frontiers in physiology · 2021Article
- Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View.International journal of molecular sciences · 2020Article
- Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Relevance of Lipid-Based Products in the Management of Dry Eye Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2017Review
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Surface properties and exponential stress relaxations of mammalian meibum films.European biophysics journal : EBJ · 2017Article
- Ocular Surface as Barrier of Innate Immunity.The open ophthalmology journal · 2015Article
- Tear instability importance, mechanisms, validity and reliability of assessment.Journal of optometryReview
- Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsReview
- Atomic force microscopy and Langmuir-Blodgett monolayer technique to assess contact lens deposits and human meibum extracts.Journal of optometryArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the current knowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick non-polar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their non-polar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional aggregates of polar lipids in both non-polar and water subphases is observed. We suggest that these three-dimensional structures are abundant under dynamic conditions caused by the action of eye lids and that they act as reservoirs of polar lipids, thus increasing stability of the tear film.
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