Evidence map›Paper›PMID 24651006›Full record

ArticleCancer cell2014

Leukemia propagating cells Akt up.

Alejandro Gutierrez, Justine E Roderick, Michelle A Kelliher

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alejandro GutierrezDivision of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. Electronic address: alejandro.gutierrez@childrens.harvard.edu.
Justine E RoderickDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Michelle A KelliherDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: michelle.kelliher@umassmed.edu.
University of Massachusetts Chan Medical School · USBoston Children's Hospital · US

Funding

Mechanism(s) of TAL-1/SCL-mediated LeukemogenesisR01CA096899 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MICHELLE ALICE KELLIHER · 2004 to 2026
$6.9M
NCI NIH HHS R01 CA096899
6 · The paper itself

Abstract

Individual cancer cells can exhibit striking differences in tumorigenic potential following experimental transplantation, but the molecular pathways that regulate this activity remain poorly understood. In this issue of Cancer Cell, Blackburn and colleagues report that Akt signaling regulates both leukemia-propagating potential and proliferation rate via distinct pathways in T-ALL.

Indexed as

AnimalsClonal EvolutionHumansMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycTOR Serine-Threonine Kinases

Identifiers

PMID24651006
OpenAlexW2049816170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.