ArticleBiochimica et biophysica acta2014
Tracing the pathway of compositional changes in bone mineral with age: preliminary study of bioapatite aging in hypermineralized dolphin's bulla.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 35 citations in OpenAlex.
- Bone Apatite Nanocrystal: Crystalline Structure, Chemical Composition, and Architecture.Biomimetics (Basel, Switzerland) · 2023Review
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- Effect of Xylo-Oligosaccharides Supplementation by Drinking Water on the Bone Properties and Related Calcium Transporters in Growing Mice.Nutrients · 2020Article
- Influences of bioapatite mineral and fibril structure on the mechanical properties of chicken bone during the laying period.Poultry science · 2019Article
- Article
- Identifying Initiation and Aging of Hens During the Laying Period by Raman Analysis of Beaks.The journal of poultry science · 2019Article
- Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization-A Surface with Application Potential in Biomaterials.Polymers · 2018Article
- Two types of bone necrosis in the Middle TriassicRoyal Society open science · 2017Article
- Protein-free formation of bone-like apatite: New insights into the key role of carbonation.Biomaterials · 2017Article
- Calcium orthophosphates (CaPOProgress in biomaterialsArticle
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2 authors at 1 institution in 1 country.
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Abstract
backgroundStudies of mineral compositional effects during bone aging are complicated by the presence of collagen.
methodsHypermineralized bullae of Atlantic bottlenose dolphins of <3months, 2.5years, and 20years underwent micrometer-scale point analysis by Raman spectroscopy and electron microprobe in addition to bulk analysis for carbon.
resultsBulla central areas have a mineral content of ~96wt.% and 9-10wt.% carbonate in their bioapatite, which is ~2wt.% more than edge areas. Ca/P atomic ratios (~1.8) and concentrations of Mg, S, and other minor/trace elements are almost constant in central areas over time. Maturity brings greater over-all homogeneity in mineral content, stoichiometry, and morphology throughout the central and edge areas of the bullae. During aging, edge areas become less porous, whereas the concentration of organics in the edge is reduced. Enhancement of coupled substitutions of CO3(2-) for PO4(3-) and Na for Ca during aging increases carbonate content up to ~10wt.% in the adult bulla.
conclusions1) Changes in physical properties during aging did not occur simultaneously with changes in chemical properties of the bone mineral. 2) Compositional changes in bone mineral were minor during the neonatal to sub-adult stage, but significant during later maturity. 3) Na and CO3 concentrations co-vary in a 1:1 molar proportion during aging. 4) The mineral's crystallinity did not decrease as CO3 concentration increased during aging. GENERAL SIGNIFICANCE: Hypermineralized dolphin's bulla, due to extreme depletion in collagen, is an ideal material for investigating mineralogical changes in bioapatite during bone aging.
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