ArticleNeurobiology of aging2014
Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease.
Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Analysis of microRNA and Gene Expression Profiles in Alzheimer's Disease: A Meta-Analysis Approach.Scientific reports · 2018Pooled it
- Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases.International journal of molecular sciences · 2024Review
- Mitochondria in Alzheimer's Disease Pathogenesis.Life (Basel, Switzerland) · 2024Review
- Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.ACS chemical neuroscience · 2021Article
- The salvageable brain in acute ischemic stroke. The concept of a reverse mismatch: a mini-review.Metabolic brain disease · 2020Review
- Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease.Current Alzheimer research · 2019Article
- Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.Brain : a journal of neurology · 2018Article
- Associations of Oxidative Phosphorylation-Related Genes With Deep Intracerebral Hemorrhage in Taiwan.Journal of experimental neuroscience · 2018Article
- Identification of molecular alterations in leukocytes from gene expression profiles of peripheral whole blood of Alzheimer's disease.Scientific reports · 2017Article
- Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Review
- RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.PloS one · 2017Article
- Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease.Oncotarget · 2016Article
- Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants.Neurology · 2016Article
- Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Previous research implicates alterations in oxidative phosphorylation (OXPHOS) in the development of Alzheimer's disease (AD). We sought to test whether genetic variants within OXPHOS genes increase the risk of AD. We first used gene-set enrichment analysis to identify associations, and then applied a previously replicated stroke genetic risk score to determine if OXPHOS genetic overlap exists between stroke and AD. Gene-set enrichment analysis identified associations between variation in OXPHOS genes and AD versus control status (p = 0.012). Conversion from cognitively normal controls to mild cognitive impairment was also associated with the OXPHOS gene-set (p = 0.045). Subset analyses demonstrated association for complex I genes (p < 0.05), but not for complexes II-V. Among neuroimaging measures, hippocampal volume and entorhinal cortex thickness were associated with OXPHOS genes (all p < 0.025). The stroke genetic risk score demonstrated association with clinical status, baseline and longitudinal imaging measures (p < 0.05). OXPHOS genetic variation influences clinical status and neuroimaging intermediates of AD. OXPHOS genetic variants associated with stroke are also linked to AD progression. Further studies are needed to explore functional consequences of these OXPHOS variants.
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Registered trials
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