Evidence map›Paper›PMID 24650760›Full record

ArticleFEBS letters2014

Drosophila melanogaster as a model system to study long-chain fatty acid amide metabolism.

Kristen A Jeffries, Daniel R Dempsey, Anita L Behari, Ryan L Anderson, David J Merkler

Abstract read
In one paragraph

Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Impact of the 294 bp SINE Insertion in 5'UTR of theAnimals : an open access journal from MDPI · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Biosynthesis and Metabolism of theFrontiers in molecular biosciences · 2021
    Review
  10. Article
  11. Article
  12. Biomolecules · 2019
    Review
  13. Article
  14. Article
  15. Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori.Prostaglandins, leukotrienes, and essential fatty acids · 2018
    Article
  16. Insect ArylalkylamineFrontiers in molecular biosciences · 2018
    Review
  17. Article
  18. Article
  19. Journal of biology and nature · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristen A JeffriesDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Daniel R DempseyDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Anita L BehariDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Ryan L AndersonDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
David J MerklerDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. Electronic address: merkler@usf.edu.

Funding

Glycine N-AcyltransferasesR03DA034323 · NIDA · UNIVERSITY OF SOUTH FLORIDA · PI MERKLER, DAVID J · 2012 to 2013
$136k
NIDA NIH HHS R03 DA034323NIDA NIH HHS R03-DA034323
6 · The paper itself

Abstract

Long-chain fatty acid amides are cell-signaling lipids identified in mammals and, recently, in invertebrates, as well. Many details regarding fatty acid amide metabolism remain unclear. Herein, we demonstrate that Drosophila melanogaster is an excellent model system for the study long-chain fatty acid amide metabolism as we have quantified the endogenous levels of N-acylglycines, N-acyldopamines, N-acylethanolamines, and primary fatty acid amides by LC/QTOF-MS. Growth of D. melanogaster on media supplemented with [1-(13)C]-palmitate lead to a family of (13)C-palmitate-labeled fatty acid amides in the fly heads. The [1-(13)C]-palmitate feeding studies provide insight into the biosynthesis of the fatty acid amides.

Indexed as

Lipid MetabolismAnimalsDrosophila melanogasterEthanolaminesPalmitic AcidsEthanolaminesPalmitic AcidsBiosynthetic pathwayDrosophila melanogasterEndogenous quantificationHeavy-labeled precursorLong-chain fatty acid amideModel system

Identifiers

PMID24650760
PMCPMC4023565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.