ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2014
Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
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- Of Sugar and Fat: How Protein Glycosylation in Sinusoidal Cells Controls Lipid Metabolism in Liver.Cellular and molecular gastroenterology and hepatology · 2024Article
- Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice.Cellular and molecular gastroenterology and hepatology · 2024Article
- Beyond the Checkpoint: Severe Axitinib-induced Liver Injury.ACG case reports journal · 2023Article
- Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis.Stem cells translational medicine · 2022Review
- TraSig: inferring cell-cell interactions from pseudotime ordering of scRNA-Seq data.Genome biology · 2022Article
- Role of YAP1 Signaling in Biliary Development, Repair, and Disease.Seminars in liver disease · 2022Review
- Angiodiversity and organotypic functions of sinusoidal endothelial cells.Angiogenesis · 2021Review
- Cellular plasticity at the nexus of development and disease.Development (Cambridge, England) · 2021Review
- PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.Cell death & disease · 2021Article
- Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation.Frontiers in physiology · 2021Article
- [Research progress of liver sinusoidal endothelial cells in the regulation of liver microenvironment to affect liver fibrosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Review
- Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Neovascularization is a key feature of liver fibrosis progression: anti-angiogenesis as an innovative way of liver fibrosis treatment.Molecular biology reports · 2020Review
- Lymphatic Programing and Specialization in Hybrid Vessels.Frontiers in physiology · 2020Review
- Review
- Emerging Roles of Vascular Endothelium in Metabolic Homeostasis.Circulation research · 2018Review
- Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.Hepatology (Baltimore, Md.) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vascular endothelial growth factor (VEGF) is crucial for vascular development in several organs. However, the specific contribution of epithelial-VEGF signaling in the liver has not been tested. We used a mouse model to specifically delete Vegf from the liver epithelial lineages during midgestational development and assessed the cell identities and architectures of epithelial and endothelial tissues. We find that without epithelial-derived VEGF, the zonal endothelial and hepatocyte cell identities are altered. We also find decreased portal vein and hepatic artery branching coincident with an increase in hepatic hypoxia postnatally. Together, these data indicate that VEGF secreted from the hepatic epithelium is required for normal differentiation of cells and establishment of three-dimensional vascular branching and zonal architectures in both epithelial and endothelial hepatic tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.