ReviewCurrent opinion in neurobiology2014
The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor?
Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Shortened Cortical Silent Period in Children with Attention Deficit Hyperactivity Disorder.medRxiv : the preprint server for health sciences · 2026Article
- TLR7-induced murine inflammation results in a global neuroinflammatory response driving neural circuit-specific transcriptomic changes.Scientific reports · 2026Article
- Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex.Science (New York, N.Y.) · 2023Article
- GABACurrent neuropharmacology · 2022Review
- CaInternational journal of molecular sciences · 2022Review
- Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cortical silent period reflects individual differences in action stopping performance.Scientific reports · 2021Article
- Impact of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex.Nature neuroscience · 2021Article
- GABAFrontiers in cellular neuroscience · 2021Article
- Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABAFrontiers in cellular neuroscience · 2020Article
- Thalamic Drive of Cortical Parvalbumin-Positive Interneurons during Down States in Anesthetized Mice.Current biology : CB · 2019Article
- CaMolecular neurobiology · 2019Article
- Article
- Optogenetic study of networks in epilepsy.Journal of neuroscience research · 2017Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Role of Somatostatin-Positive Cortical Interneurons in the Generation of Sleep Slow Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Convention holds that ionotropic receptors mediate fast neurotransmission and that 'slow' G-protein coupled metabotropic receptors have a secondary, modulatory role in the control of neuronal networks. Here, we discuss recent evidence showing that activation of metabotropic GABAB receptors in cortical layer 1 can powerfully inhibit principal cell activity and that their activation can rapidly halt ongoing network activity. Inputs from both within and without the cortex converge upon layer 1 where they target various populations of interneurons, including neurogliaform cells. We argue that neurogliaform cells are the main effector of a powerful inhibitory circuit that, acting through GABAB receptors, can be differentially recruited by long-range connections to serve in roles as diverse as conscious perception and memory consolidation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.