ArticlePsychiatry research2014
Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia.
Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Diffusion Tensor MR Imaging Evaluation of Callosal Abnormalities in Schizophrenia: A Meta-Analysis.PloS one · 2016Pooled it
- An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated With Psychopathology Across Independent Cohorts.Biological psychiatry · 2025Article
- Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.Translational psychiatry · 2021Article
- Voxel-Wise Feature Selection Method for CNN Binary Classification of Neuroimaging Data.Frontiers in neuroscience · 2021Article
- Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia.Translational psychiatry · 2020Article
- Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in mice.Brain research bulletin · 2020Article
- White matter structure in schizophrenia and autism: Abnormal diffusion across the brain in schizophrenia.Neuropsychologia · 2019Article
- Abnormal Brain Structure and Function in First-Episode Childhood- and Adolescence-Onset Schizophrenia: Association with Clinical Symptoms.Neuroscience bulletin · 2019Article
- Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.Brain and behavior · 2019Article
- Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia.Translational psychiatry · 2018Article
- S-Ketamine-Induced NMDA Receptor Blockade during Natural Speech Production and Its Implications for Formal Thought Disorder in Schizophrenia: A Pharmaco-fMRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Altered White Matter Connectivity Within and Between Networks in Antipsychotic-Naive First-Episode Schizophrenia.Schizophrenia bulletin · 2018Article
- Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study.Schizophrenia research · 2017Article
- White matter microstructural deficits in 22q11.2 deletion syndrome.Psychiatry research. Neuroimaging · 2017Article
- 3D imaging of the brain morphology and connectivity defects in a model of psychiatric disorders: MAP6-KO mice.Scientific reports · 2017Article
- Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients.Frontiers in psychiatry · 2017Article
- A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophrenia.Schizophrenia research · 2016Article
- Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up.Schizophrenia research · 2015Article
- Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample.Schizophrenia research · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not been fully explored. DTI data were acquired from twenty-four patients with chronic schizophrenia and twenty-five healthy controls. Regional brain abnormalities were evaluated by conducting FA comparisons in the cerebral and each lobar WMs between groups. Focal abnormalities were also evaluated with a voxel-wise tract specific method. Associations between structural WM changes and negative symptoms were assessed using the Scale for the Assessment of Negative Symptoms (SANS). The patient group showed decreased FA in the cerebrum, especially in the frontal lobe, compared with controls. A voxel-wise analysis showed FA decreases in almost all WM tracts in schizophrenia. Correlation analyses demonstrated negative relationships between FA in the cerebrum, particularly in the left hemisphere, and SANS global and global rating scores (Anhedonia-Asociality, Attention, and Affective-Flattening), and also associations between FA of left frontal lobe and SANS global score, Anhedonia-Asociality, and Attention. This study demonstrates that patients with chronic schizophrenia evince widespread cerebral FA abnormalities and that these abnormalities, especially in the left hemisphere, are associated with negative symptoms.
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