Evidence map›Paper›PMID 24650325›Full record

ArticleBMC medical genomics2014

PhenX RISING: real world implementation and sharing of PhenX measures.

Catherine A McCarty, Wayne Huggins, Allison E Aiello, Robert M Bilder, Ahmad Hariri, Terry L Jernigan, Erik Newman, Dharambir K Sanghera, Timothy J Strauman, Yi Zeng and 3 more

Abstract read
In one paragraph

Article in BMC medical genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  11. Analyzing Real-World Use of Research Common Data Elements.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Using the PhenX Toolkit to Add Standard Measures to a Study.Current protocols in human genetics · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Catherine A McCartyEssentia Institute of Rural Health, Maildrop: 6AV-2, 502 East Second Street, Duluth, MN 55805, USA. cmccarty@eirh.org.
Wayne Huggins
Allison E Aiello
Robert M Bilder
Ahmad Hariri
Terry L Jernigan
Erik Newman
Dharambir K Sanghera
Timothy J Strauman
Yi Zeng
Erin M Ramos
Heather A Junkins
PhenX RISING network

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Building Consensus for Standard Measures for Genome-Wide Association StudiesU01HG004597 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2007 to 2012
$11.1M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Human Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8M
Ecologic Stressors, PTSD, and Drug Use in DetroitR01DA022720 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AIELLO, ALLISON E · 2007 to 2011
$4.7M
IRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1M
Demographic Analysis on Determinants of Healthy Longevity in ChinaR01AG023627 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2004 to 2014
$3.9M
Mapping Individual Cognitive Differences to Neural Variance and School ReadinessR01HD061414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2010 to 2014
$3.3M
Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in AsianR01DK082766 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SANGHERA, DHARAMBIR K. · 2009 to 2011
$2.3M
Self-Regulation Failure: Identifying and Modifying a Risk PhenotypeR01DA031579 · NIDA · DUKE UNIVERSITY · PI HARIRI, AHMAD R., STRAUMAN, TIMOTHY J · 2010 to 2012
$1.9M
NCATS NIH HHS UL1 TR000427NHGRI NIH HHS 3U01 HG006389-01S1NHGRI NIH HHS U01HG004597NIA NIH HHS 3R01AG023627-06A2S1NICHD NIH HHS R01 HD061414NICHD NIH HHS R01 HD61414NIDA NIH HHS 3R01 DA031579-02S1NIDA NIH HHS 3RC2 DA029475-02S1NIDA NIH HHS R01 DA022720-05S1NIDDK NIH HHS R01 DK082766NIDDK NIH HHS R01DK082766-03S1NIMH NIH HHS 3PL1 MH083271-05S1
6 · The paper itself

Abstract

backgroundThe purpose of this manuscript is to describe the PhenX RISING network and the site experiences in the implementation of PhenX measures into ongoing population-based genomic studies.

methodsEighty PhenX measures were implemented across the seven PhenX RISING groups, thirty-three of which were used at more than two sites, allowing for cross-site collaboration. Each site used between four and 37 individual measures and five of the sites are validating the PhenX measures through comparison with other study measures. Self-administered and computer-based administration modes are being evaluated at several sites which required changes to the original PhenX Toolkit protocols. A network-wide data use agreement was developed to facilitate data sharing and collaboration.

resultsPhenX Toolkit measures have been collected for more than 17,000 participants across the PhenX RISING network. The process of implementation provided information that was used to improve the PhenX Toolkit. The Toolkit was revised to allow researchers to select self- or interviewer administration when creating the data collection worksheets and ranges of specimens necessary to run biological assays has been added to the Toolkit.

conclusionsThe PhenX RISING network has demonstrated that the PhenX Toolkit measures can be implemented successfully in ongoing genomic studies. The next step will be to conduct gene/environment studies.

Indexed as

Gene-Environment InteractionSurveys and QuestionnairesAdultAgedAsian PeopleChildChinaCognitionDiabetes MellitusFemaleHumansIndiaLongitudinal StudiesMaleMiddle AgedPhenotype

Identifiers

PMID24650325
PMCPMC3994539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.