ArticleAmerican journal of respiratory and critical care medicine2014
Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock.
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
- Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial.Critical care (London, England) · 2017Trial
- A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Trial
- Trial
- Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis.Frontiers in pharmacology · 2026Review
- Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock.Scientific reports · 2025Article
- Identification of the Shared Gene Signatures of HCK, NOG, RNF125 and Biological Mechanism in Pediatric Acute Lymphoblastic Leukaemia and Pediatric Sepsis.Molecular biotechnology · 2025Article
- Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets.Frontiers in pediatrics · 2025Article
- Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.Scientific reports · 2024Article
- PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis.Briefings in bioinformatics · 2024Article
- scCaT: An explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing.PLoS computational biology · 2024Article
- Article
- Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning.World journal of pediatrics : WJP · 2023Article
- Interrogating the sepsis host immune response using cytomics.Critical care (London, England) · 2023Review
- Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile.Critical care explorations · 2023Article
- Validating a Proteomic Signature of Severe COVID-19.Critical care explorations · 2022Article
- Article
- Long non-coding RNA pairs to assist in diagnosing sepsis.BMC genomics · 2021Article
- Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome.Critical care (London, England) · 2020Observational
- Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation.PloS one · 2020Article
- Transient hypertrophic cardiomyopathy and hypertension associated with hydrocortisone in preterm infant: A case report.Medicine · 2019Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 1 country.
Funding
Abstract
rationaleCorticosteroids are prescribed commonly for patients with septic shock, but their use remains controversial and concerns remain regarding side effects.
objectivesTo determine the effect of adjunctive corticosteroids on the genomic response of pediatric septic shock.
methodsWe retrospectively analyzed an existing transcriptomic database of pediatric septic shock. Subjects receiving any formulation of systemic corticosteroids at the time of blood draw for microarray analysis were classified in the septic shock corticosteroid group. We compared normal control subjects (n = 52), a septic shock no corticosteroid group (n = 110), and a septic shock corticosteroid group (n = 70) using analysis of variance. Genes differentially regulated between the no corticosteroid group and the corticosteroid group were analyzed using Ingenuity Pathway Analysis. MEASUREMENTS AND MAIN
resultsThe two study groups did not differ with respect to illness severity, organ failure burden, mortality, or mortality risk. There were 319 gene probes differentially regulated between the no corticosteroid group and the corticosteroid group. These genes corresponded predominately to adaptive immunity-related signaling pathways, and were down-regulated relative to control subjects. Notably, the degree of down-regulation was significantly greater in the corticosteroid group, compared with the no corticosteroid group. A similar pattern was observed for genes corresponding to the glucocorticoid receptor signaling pathway.
conclusionsAdministration of corticosteroids in pediatric septic shock is associated with additional repression of genes corresponding to adaptive immunity. These data should be taken into account when considering the benefit to risk ratio of adjunctive corticosteroids for septic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.