Evidence map›Paper›PMID 24650213›Full record

ArticleJournal of agricultural and food chemistry2014

Detection of anthocyanins/anthocyanidins in animal tissues.

Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Jian Cai, Inder P Singh, Ramesh C Gupta

Open access · bronzeAbstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Blueberry (Foods (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Review
  7. In vivo antioxidant activity of rabbiteye blueberry (Journal of Zhejiang University. Science. B · 2023
    Article
  8. Article
  9. Review
  10. Anthocyanins and Their CMolecules (Basel, Switzerland) · 2019
    Review
  11. Article
  12. Leaf Extracts ofFrontiers in microbiology · 2017
    Article
  13. Prevention of hormonal breast cancer by dietary jamun.Molecular nutrition & food research · 2016
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Farrukh AqilJames Graham Brown Cancer Center, ‡Department of Medicine, and #Department of Pharmacology and Toxicology, University of Louisville , Louisville, Kentucky 40202, United States.
Manicka V Vadhanam
Jeyaprakash Jeyabalan
Jian Cai
Inder P Singh
Ramesh C Gupta
National Institute of Pharmaceutical Education and Research · IN

Funding

Breast Cancer Chemoprevention StrategiesR01CA118114 · NCI · UNIVERSITY OF LOUISVILLE · PI GUPTA, RAMESH C · 2007 to 2010
$1.5M
Breast Cancer Chemoprevention Potential of Common SpicesR01CA125152 · NCI · UNIVERSITY OF LOUISVILLE · PI GUPTA, RAMESH C · 2007 to 2011
$1.4M
NCI NIH HHS CA-118114NCI NIH HHS CA125152
6 · The paper itself

Abstract

Dietary polyphenols may contribute to the prevention of several degenerative diseases, including cancer. Anthocyanins have been shown to possess potential anticancer activity. The aim of this study was to determine anthocyanin bioavailability in lung tissue of mice fed a blueberry diet (5% w/w) for 10 days or a bolus dose (10 mg/mouse; po) of a native mixture of bilberry anthocyanidins. All five anthocyanidins present in the blueberry were detected in the lung tissue using improved methods. The effect of various solvents on the stability of anthocyanins and their recovery from the biomatrix was analyzed. Detection of anthocyanins and their metabolites was performed by UPLC and LC-MS. Although anthocyanins were not detected, cyanidin was detected by UPLC-PDA and other anthocyanidins were detected by LC-MS, following conversion to anthocyanidins and selective extraction in isoamyl alcohol. The results show that anthocyanins can be detected in lung tissue of blueberry-fed mice and thus are bioavailable beyond the gastrointestinal tract.

Indexed as

AnimalsAnthocyaninsBlueberry PlantsChromatography, High Pressure LiquidFemaleLungMass SpectrometryMiceMice, NudePlant ExtractsAnthocyaninsPlant Extractsanthocyanidinsanthocyaninsbioavailabilityblueberry dietlung tissue

Identifiers

PMID24650213
PMCPMC4334289
OpenAlexW2094285845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.