ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2014
Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA lung study.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The relationship between genetic prediction of 486 blood metabolites and the risk of COPD: mendelian randomization study.Scientific reports · 2025Article
- Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study.ERJ open research · 2023Article
- A Metabolomic Severity Score for Airflow Obstruction and Emphysema.Metabolites · 2022Article
- Metabolomics Reveals Dysregulated Sphingolipid and Amino Acid Metabolism Associated with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD.Medicine and science in sports and exercise · 2021Article
- Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.British journal of pharmacology · 2020Article
- Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study.American journal of respiratory and critical care medicine · 2019Article
- Pre-analytic Considerations for Mass Spectrometry-Based Untargeted Metabolomics Data.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Article
- Changes of plasmalogen phospholipid levels during differentiation of induced pluripotent stem cells 409B2 to endothelial phenotype cells.Scientific reports · 2017Article
- Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1-p38-Xanthine Oxidoreductase-Dependent Cigarette Smoke-Induced Apoptosis.American journal of respiratory cell and molecular biology · 2016Article
- Intercellular adhesion molecule 1 and progression of percent emphysema: the MESA Lung Study.Respiratory medicine · 2015Article
- Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.American journal of respiratory and critical care medicine · 2015Article
- Bioactive lipids in emphysema. Decoding fat to reveal COPD phenotypes.American journal of respiratory and critical care medicine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
contextCeramide causes endothelial apoptosis and emphysema-like changes in animal models.
objectivesTest if plasma sphingomyelin, a major precursor of ceramide, would predict longitudinal increase in the percentage of emphysema-like lung on computed tomography (CT). MATERIALS AND
methods3840 participants had their plasma sphingomyelin measured at baseline examination and their pulmonary emphysema measured on cardiac CT scans at baseline and on follow-up visits. Mixed effects models were used to adjust for potential confounders.
resultsOne standard deviation increase in sphingomyelin predicted a 0.12% per year (95% CI: 0.02-0.22; p = 0.019) greater increase of percent emphysema. DISCUSSION AND
conclusionHigher plasma levels of sphingomyelin predicted greater annual increase in quantitatively measured percent emphysema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.