Evidence map›Paper›PMID 24649434›Full record

ArticleQuantitative imaging in medicine and surgery2014

In vivo evaluation of optic nerve aging in adult rhesus monkey by diffusion tensor imaging.

Yumei Yan, Longchuan Li, Todd M Preuss, Xiaoping Hu, James G Herndon, Xiaodong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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  8. Parallel and sparse MR imaging: methods and instruments-Part 1.Quantitative imaging in medicine and surgery · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yumei Yan1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Longchuan Li1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Todd M Preuss1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Xiaoping Hu1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
James G Herndon1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Xiaodong Zhang1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 2 Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia 30322, USA ; 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA ; 4 The Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
SOCIAL COGNITION AND EMOTIONAL AGING IN PRIMATESP01AG026423 · NIA · EMORY UNIVERSITY · PI HERNDON, JAMES G · 2007 to 2011
$11.6M
NCRR NIH HHS P51 RR000165NIA NIH HHS P01 AG026423NIH HHS P51 OD011132
6 · The paper itself

Abstract

Aging of the optic nerve can result in reduced visual sensitivity or vision loss. Normal optic nerve aging has been investigated previously in tissue specimens but poorly explored in vivo. In the present study, the normal aging of optic nerve was evaluated by diffusion tensor imaging (DTI) in non-human primates. Adult female rhesus monkeys at the ages of 9 to 13 years old (young group, n=8) and 21 to 27 years old (old group, n=7) were studied using parallel-imaging-based DTI on a clinical 3T scanner. Compared to young adults, the old monkeys showed 26% lower fractional anisotropy (P<0.01), and 44% greater radial diffusivity, although the latter difference was of marginal statistical significance (P=0.058). These MRI findings are largely consistent with published results of light and electron microscopic studies of optic nerve aging in macaque monkeys, which indicate a loss of fibers and degenerative changes in myelin sheaths.

Indexed as

fractional anisotropy (FA)GRAPPAmean diffusivity (MD)non-human primateOptic nerve agingparallel imagingwhite matter

Identifiers

PMID24649434
PMCPMC3947981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.