Evidence map›Paper›PMID 24649399›Full record

ArticleFEBS open bio2014

Detection of changes in the structure and distribution map of triacylglycerol in fatty liver model by MALDI-SpiralTOF.

Kahoko Nishikawa, Masahiro Hashimoto, Yoshiyuki Itoh, Sadayuki Hiroi, Akihiko Kusai, Fumihiko Hirata, Toshihisa Sakamoto, Keiichi Iwaya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Evolution of the liver biopsy and its future.Translational gastroenterology and hepatology · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kahoko NishikawaDepartment of Traumatology and Critical Care Medicine, National Defense Medical College, Saitama 359-8513, Japan.
Masahiro HashimotoJEOL Ltd., Akishima, Tokyo 196-8553, Japan.
Yoshiyuki ItohJEOL Ltd., Akishima, Tokyo 196-8553, Japan.
Sadayuki HiroiDepartment of Laboratory Medicine, National Defense Medical College, Saitama 359-8513, Japan.
Akihiko KusaiJEOL Ltd., Akishima, Tokyo 196-8553, Japan.
Fumihiko HirataJapan Self Defense Forces Hospital Yokosuka, Kanagawa 237-0071, Japan.
Toshihisa SakamotoDepartment of Traumatology and Critical Care Medicine, National Defense Medical College, Saitama 359-8513, Japan.
Keiichi IwayaDepartment of Pathology, National Defense Medical College, Saitama 359-8513, Japan.
National Defense Medical College · JPJEOL (Japan) · JPSelf-Defense Forces Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionisation spiral orbit-type time-of-flight mass spectrometry (MALDI-SpiralTOF) can analyse lipid profiles and characterise lipid structure. Imaging mass spectrometry (IMS) also provides distribution maps of selected m/z values. Here, we investigated triacylglycerol (TG) structure and distribution using these technologies to estimate mouse fatty liver. The distribution and intensity of the most intense mass spectrum ion was indicated by IMS at m/z 881.7 (52:2). Analysis using MS/MS showed a structural change between liver TG and dietary TG. These findings suggest that MALDI-SpiralTOF is a powerful tool for clinical screening and estimating fatty liver.

Indexed as

CID, collision-induced dissociationFatty liverHE, haematoxlylin and eosinHF, high-fat dietHF + Res, high-fat diet supplemented with 0.2% resveratrolImaging mass spectrometryIMS, imaging mass spectrometryMALDI-SpiralTOF, matrix-assisted laser desorption/ionisation spiral orbit-type time-of-flight mass spectrometryMatrix-assisted laser desorption/ionisationSpiral orbit-type time-of-flight mass spectrometerTG, triacylglycerolTOF/TOF, tandem time-of-flightTriacylglycerol

Identifiers

PMID24649399
PMCPMC3953719
OpenAlexW1993653346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.