ArticleBiomedical reports2013
Clinical value of circulating liver cancer cells for the diagnosis of hepatocellular carcinoma: A meta-analysis.
Article in Biomedical reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02416635 (The Detection of Circulating Tumor Cells), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Detection of Circulating Tumor Cells (CTCs) in Patients With Liver Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Utility of Liquid Biopsy Analysis in Detection of Hepatocellular Carcinoma, Determination of Prognosis, and Disease Monitoring: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020Pooled it
- Pooled it
- Prognostic value of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- Hepatocellular carcinoma biology predicts survival outcome after liver transplantation in the USA.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Detecting Tumor Metastases: The Road to Therapy Starts Here.Advances in cancer research · 2016Review
- Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology.BMC clinical pathology · 2015Article
- Biomarkers for hepatocellular carcinoma: diagnostic and therapeutic utility.Hepatic medicine : evidence and research · 2015Review
- Circulating Tumor Cell Isolation and Analysis.Advances in clinical chemistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was conducted to evaluate the clinical value of circulating tumor cells (CTCs) for liver tumor size, clinical stage and metastasis. The clinical studies on CTCs and liver cancer were electronically and manually retrieved and Review Manager 5.1 software was used to evaluate the quality of the obtained studies, extract data and conduct a meta-analysis. A total of 5 studies including 535 liver cancer patients were identified. The results of the meta-analysis revealed that the odds ratio (OR) values of CTCs-positive rates between large and small tumor size, tumor stage I/II and III/IV, as well as metastatic and non-metastatic groups were 12.12 (95% CI: 7.84-18.74), 0.10 (95% CI: 0.07-0.16) and 0.09 (95% CI: 0.05-0.15), respectively, which demonstrated a significant difference. In conclusion, the detection of CTCs in the peripheral blood was clearly associated with tumor size, clinical stage and metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.