Evidence map›Paper›PMID 24648943›Full record

ArticleBiomedical reports2013

Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells.

Meng Song, Xueping Ou, Cuicui Xiao, Zhongming Xiao, Fang Wei, Yan Hong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meng SongDepartments of Stomatology, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Xueping OuDepartments of Stomatology, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Cuicui XiaoDepartments of Stomatology, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Zhongming XiaoExperimental Research Center, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Fang WeiExperimental Research Center, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Yan HongExperimental Research Center, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. China.
Shanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleomorphic adenoma is the most common benign neoplasm of the salivary gland. Few studies are currently available on pleomorphic adenoma cell apoptosis. The aim of this study was to investigate the effect of cyclopamine induction apoptosis in human salivary pleomorphic adenoma (HSPA) cells and the impact on Gli2 and Bcl2 mRNA levels. Cells were quantified and cell morphology was visualized under microscope. Flow cytometry was used to detect the apoptotic rate. Cyclopamine is considered an efficient blocker of the hedgehog (Hh) signaling pathway. Following treatment with 10

Indexed as

apoptosisBcl2cyclopamineGli2pleomorphic adenoma cell

Identifiers

PMID24648943
PMCPMC3917731
OpenAlexW2082354484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.