Evidence map›Paper›PMID 24648867›Full record

ArticleACS medicinal chemistry letters2013

Chiral Effect of a Phe Residue in Position 3 of the Dmt

Yeon Sun Lee, Hong Chang Qu, Peg Davis, Shou-Wu Ma, Ruben Vardanyan, Josephine Lai, Frank Porreca, Victor J Hruby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Structure-Activity Relationships of [des-ArgJournal of medicinal chemistry · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yeon Sun LeeDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Hong Chang QuDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Peg DavisDepartment of Pharmacology, University of Arizona, Tucson, Arizona 85721, United States.
Shou-Wu MaDepartment of Pharmacology, University of Arizona, Tucson, Arizona 85721, United States.
Ruben VardanyanDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Josephine LaiDepartment of Pharmacology, University of Arizona, Tucson, Arizona 85721, United States.
Frank PorrecaDepartment of Pharmacology, University of Arizona, Tucson, Arizona 85721, United States.
Victor J HrubyDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.

Funding

NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

In this letter, we describe a structure-activity relationships study, specifically related to the chirality of third amino acid residue in our H-Dmt-L(or D)-Tic analogues, of which C-terminus is attached to a piperidinyl moiety. Observed selectivities and functional activities of these analogues demonstrated that the chiralities of the second and third position residues are crucial for determining whether these ligands act as antagonists or agonists at the

Indexed as

chiralityDmt-Ticopioid functional activitiesstructure–activity relationshipδ opioid receptor

Identifiers

PMID24648867
PMCPMC3956057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.