Evidence map›Paper›PMID 24648842›Full record

ArticleInternational journal of dentistry2014

Impact of an anticaries mouthrinse on in vitro remineralization and microbial control.

Frank C Sun, E Eric Engelman, James A McGuire, Gabrielle Kosmoski, Lauren Carratello, Danette Ricci-Nittel, Jane Z Zhang, Bruce R Schemehorn, Robert J Gambogi

Abstract read
In one paragraph

Article in International journal of dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Inhibition of the Biofilm Formation of PlantPharmaceuticals (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frank C SunJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
E Eric EngelmanJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
James A McGuireJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
Gabrielle KosmoskiJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
Lauren CarratelloJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
Danette Ricci-NittelJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
Jane Z ZhangJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.
Bruce R SchemehornDental Product Testing, Therametric Technologies, Inc., 9880 Douglas Floyd Parkway, Noblesville, IN, USA.
Robert J GambogiJohnson & Johnson Consumer & Personal Product Worldwide, Skillman, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. The objective of this research was to evaluate the caries control potential of a new fluoride mouthrinse that also contained antimicrobial agents and a biofilm disrupting agent using different in vitro models. Methods. Four in vitro studies were conducted to assess the performance of this three pronged approach to caries control: (1) traditional enamel fluoride uptake, (2) surface microhardness study using pH cycling model and subsequent fluoride uptake, (3) a salivary biofilm flow-through study to determine the anti-microbial activity, and (4) a single species biofilm model measuring effect on biofilm matrix disruption. Results. The data showed that a LISTERINE rinse with fluoride, essential oils and xylitol was superior in promoting enamel fluoride uptake and in enhancing antimicrobial activity over traditional commercially available fluoridated products. An increase of the surface microhardness was observed when the LISTERINE rinse was used in combination with fluoridated toothpaste versus the fluoridated toothpaste alone. Finally, it was demonstrated that xylitol solutions disrupted and reduced the biovolume of biofilm matrix of mature Streptococcus mutans. Conclusion. These in vitro studies demonstrated that a fluoride mouthrinse with antimicrobial agent and biofilm matrix disrupting agent provided multifaceted and enhanced anti-caries efficacy by promoting remineralization, reducing acidogenic bacteria and disrupting biofilm matrix.

Identifiers

PMID24648842
PMCPMC3933167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.