ArticleClinical and experimental gastroenterology2014
Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome.
Article in Clinical and experimental gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Systematic review of the management options available for low anterior resection syndrome (LARS).Techniques in coloproctology · 2025Pooled it
- Exploring Symptom Domains of Postoperative Bowel Dysfunction by Integrating LARS and Wexner Scores: A Longitudinal Factor-Analytic Study.Annals of gastroenterological surgery · 2026Article
- Pharmacological Therapies for Bowel Dysfunction After Colorectal Cancer Surgery: A Systematic Review.Advanced pharmaceutical bulletin · 2026Review
- Efficacy and safety of the traditional Chinese medicine formulation BL-1 for the treatment of low anterior resection syndrome: study protocol for a double-blind, randomized, placebo-controlled trial.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Article
- Low anterior resection syndrome after rectal cancer surgery: mechanisms, assessment, management, and the potential role of robotic surgery.Frontiers in oncology · 2026Review
- Review
- Truly Inevitable-Our Perspective on the Complications After Surgery for Rectal Cancer.Indian journal of surgical oncology · 2025Article
- Article
- Article
- Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment.Cancers · 2023Review
- Low anterior resection syndrome.Annals of gastroenterological surgery · 2023Review
- Machine learning model for prediction of low anterior resection syndrome following laparoscopic anterior resection of rectal cancer: A multicenter study.World journal of gastroenterology · 2023Article
- Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer.Cancers · 2023Review
- Can the POLARS tool accurately predict low anterior resection syndrome in rectal cancer patients undergoing laparoscopic resection?Archives of medical science : AMS · 2023Article
- Effect of local ozone treatment on rats with anterior rectal resection and the possible mechanisms.Biomedical engineering online · 2021Article
- [Low anterior resection syndrome-Causes and treatment approaches].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Optimising functional outcomes in rectal cancer surgery.Langenbeck's archives of surgery · 2021Review
- Low Anterior Resection Syndrome.Current gastroenterology reports · 2020Review
- Etiology and management of low anterior resection syndrome based on the normal defecation mechanism.Surgery today · 2019Review
- Postoperative Bowel Function After Anal Sphincter-Preserving Rectal Cancer Surgery: Risks Factors, Diagnostic Modalities, and Management.Annals of coloproctology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSerotonin (5-hydroxytryptamine [5-HT])3 receptor antagonists are effective for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), in which exaggerated intestinal/colonic hypermotility is often observed. Recent studies have suggested that the motility disorder, especially spastic hypermotility, seen in the neorectum following sphincter-preserving operations for rectal cancer may be the basis of the postoperative defecatory malfunction seen in these patients. We investigated the efficacy of 5-HT3 receptor antagonists in patients suffering from severe low anterior resection syndrome. PATIENTS AND
methodsA total of 25 male patients with complaints of uncontrollable urgency or fecal incontinence following sphincter-preserving operations were enrolled in this study. Defecatory status, assessed on the basis of incontinence score (0-20), urgency grade (0-3), and number of toilet visits per day, was evaluated using a questionnaire before and 1 month after the administration of the 5-HT3 antagonist ramosetron.
resultsAll the parameters assessed improved significantly after taking ramosetron for 1 month. The effect was more prominent in cases whose anastomotic line was lower, ie, inside the anal canal. Defecatory function was better in patients who commenced ramosetron therapy within 6 months postoperatively, as compared to those who were not prescribed ramosetron for more than 7 months postoperatively.
conclusionThese results suggest that 5-HT3 antagonists are effective for the treatment of low anterior resection syndrome, as in diarrhea-predominant irritable bowel syndrome. The improvement in symptoms is not merely time dependent, but it is related to treatment with 5-HT3 antagonists.
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