Evidence map›Paper›PMID 24648744›Full record

ArticleOncoTargets and therapy2014

Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients.

Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Li-Jen Liao, Yu-Chin Lin, Ying-Shiung Kuo, Wu-Chia Lo, Chien-Fu Tseng, Hui-Ju Tien, Hsiu-Ling Chou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Impact of upgraded radiotherapy system on outcomes in postoperative head and neck squamous cell carcinoma patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chen-Hsi HsiehDepartment of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan ; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Pei-Wei ShuengDepartment of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan ; Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan.
Li-Ying WangSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Li-Jen LiaoDepartment of Otolaryngology, Oriental Institute of Technology, Taipei, Taiwan.
Yu-Chin LinDivision of Medical Oncology and Hematology, Department of Internal Medicine, Oriental Institute of Technology, Taipei, Taiwan.
Ying-Shiung KuoDepartment of Dentistry and Oral Surgery, Oriental Institute of Technology, Taipei, Taiwan.
Wu-Chia LoDepartment of Otolaryngology, Oriental Institute of Technology, Taipei, Taiwan.
Chien-Fu TsengDepartment of Dentistry and Oral Surgery, Oriental Institute of Technology, Taipei, Taiwan.
Hui-Ju TienDepartment of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Hsiu-Ling ChouDepartment of Nursing, Far Eastern Memorial Hospital, Oriental Institute of Technology, Taipei, Taiwan ; Department of Nursing, Oriental Institute of Technology, Taipei, Taiwan.
Yen-Ping HsiehDepartment of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, Taiwan.
Le-Jung WuDepartment of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Yu-Jen ChenInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan ; Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan ; Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan.
Far Eastern Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWNational Taichung University of Science and Technology · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC) patients receiving helical tomotherapy (HT) remains limited. MATERIALS AND

methodsBetween November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled.

resultsThe 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012). Eleven (20.8%) patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3%) in the primary area and three of 53 (5.7%) in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8%) experienced out-of-field failure. The rates of grade 3 dermatitis, mucositis, and dysphagia were 11%, 34%, and 13%, respectively. No grade 3 xerostomia was noted. Grade 2 xerostomia was 33% at month 6 and declined to 0 at month 48. A rate of 56% of grade 2 trismus at month 6 was noted, and declined to around 30% after 2 years. No grade 3 trismus was noted after 2 years.

conclusionHT as a postoperative modality provided satisfying results, especially for xerostomia and trismus, and was impressive in high- and intermediate-risk OCC patients receiving postoperative HT.

Indexed as

concurrent chemoradiationhelical tomotherapylocoregional control rateoral cavity cancertrismus

Identifiers

PMID24648744
PMCPMC3956740
OpenAlexW1968716028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.