ArticleInternational journal of nanomedicine2014
Cytotoxicity and genotoxicity caused by yttrium oxide nanoparticles in HEK293 cells.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 97 citations in OpenAlex.
- PrNanomaterials (Basel, Switzerland) · 2025Review
- Potential Applications of Rare Earth Metal Nanoparticles in Biomedicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.International journal of nanomedicine · 2025Article
- Yttrium oxide nanoparticles ameliorates calcium hydroxide and calcium titanate nanoparticles induced genomic DNA and mitochondrial damage, ROS generation and inflammation.Scientific reports · 2024Article
- Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells.BMC cancer · 2023Article
- Phytotoxicity and the molecular response in yttrium oxide nanoparticle-treated Arabidopsis thaliana seedlings.Protoplasma · 2023Article
- Sustainable Green Synthesis of Yttrium Oxide (YNanomaterials (Basel, Switzerland) · 2022Article
- Development of Oxadiazole-Sulfonamide-Based Compounds as Potential Antibacterial Agents.ACS omega · 2021Article
- YMolecules (Basel, Switzerland) · 2021Article
- 4-Hydroxyhalcone effects on cisplatin-induced genotoxicity model.Toxicology research · 2021Article
- Cytotoxicity and biocompatibility of high mol% yttria containing zirconia.Restorative dentistry & endodontics · 2020Article
- High Surface Reactivity and Biocompatibility of YMolecules (Basel, Switzerland) · 2020Article
- Computational approaches: discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds.BMC chemistry · 2019Article
- Docking predictions basedBMC chemistry · 2019Article
- 4-(2-(1BMC chemistry · 2019Article
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- Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods.Materials (Basel, Switzerland) · 2018Review
- Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.Chemistry Central journal · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increased use of engineered nanoparticles (NPs) has caused new concerns about the potential exposure to biological systems and the potential risk that these materials may pose on human health. Here, we examined the effects of exposure to different concentrations (0-50 μg/mL) and incubation times (10 hours, 24 hours, or 48 hours) of yttrium oxide (Y2O3) NPs on human embryonic kidney (HEK293) cells. Changes in cellular morphology, cell viability, cell membrane integrity, reactive oxygen species levels, mitochondrial membrane potential, cell death (apoptosis and necrosis), and the DNA damage after NP exposure were compared to the effects seen following incubation with paraquat, a known toxicant.
resultsThe 24-hour inhibitory concentration 50 (IC50) of Y2O3 NPs (41 ± 5 nm in size) in the HEK293 cells was found to be 108 μg/mL. Incubation with Y2O3 NPs (12.25-50 μg/mL) increased the ratio of Bax/Bcl-2, caspase-3 expression and promoted apoptotic- and necrotic-mediated cell death in both a concentration and a time-dependent manner. Decreases in cell survivability were associated with elevations in cellular reactive oxygen species levels, increased mitochondrial membrane permeability, and evidence of DNA damage, which were consistent with the possibility that mitochondria impairment may play an important role in the cytotoxic response.
conclusionThese data demonstrate that the Y2O3 NP exposure is associated with increased cellular apoptosis and necrosis in cultured HEK293 cells.
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