ArticleCurrent therapeutic research, clinical and experimental2011
A simple contact heat experimental pain model for evaluation of analgesic agents in healthy volunteers.
Article in Current therapeutic research, clinical and experimental, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Is heat pain detection threshold associated with the area of secondary hyperalgesia following brief thermal sensitization? A study of healthy volunteers - design and detailed plan of analysis.BMC anesthesiology · 2016Trial
- Trial
- Neural effects of cathodal transcranial direct current stimulation over left supramarginal gyrus on cognitive empathy for pain.Cognitive, affective & behavioral neuroscience · 2026Article
- Article
- Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers.Journal of pain research · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman experimental pain models help to understand the mechanism of the underlying clinical pain conditions and can be adopted to test analgesic efficacy of drugs used in the management of pain. In early phases, the clinical development of new analgesic agents is severely hindered due to lack of reliable sensitive tests for the experimental pain models.
objectiveThe aim of the present study was to standardize and validate a simple contact heat pain model that can be used for future screening of various analgesic agents.
methodsThe method was standardized by recording heat detection and heat pain detection threshold in degrees centigrade in 24 healthy volunteers. Reproducibility of the test procedure was evaluated by recording the thermal threshold parameters by a single observer on 2 sessions (inter-day reproducibility) and a second observer on 1 session (inter-observer reproducibility) separately. Validity of model was further tested by evaluating the analgesic effect of tramadol on 12 healthy volunteers.
resultsThermal pain model using contact heat method was found to produce low variability with coefficient of variation <5%. Inter-observer and inter-day reproducibility was very good, as shown by Bland-Altman Plot; with most of the values within 2 SD. There was a significant difference in both heat detection threshold and heat pain detection threshold produced by tramadol, as compared with placebo (P < 0.05).
conclusionsThe newly developed pain model produces a type of experimental pain that is responsive to analgesic effects of tramadol at clinically relevant doses. The model might be useful in early screening of new therapeutic agents before proceeding to expensive clinical trials in acute and chronic pain sufferers.
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