Evidence map›Paper›PMID 24648581›Full record

ArticleCurrent therapeutic research, clinical and experimental2011

In Vitro Antifungal Activity of Ankaferd Blood Stopper Against Candida albicans.

Sevgi Ciftci, Fahriye Keskin, Sema Keceli Ozcan, Mehmet Ali Erdem, Burak Cankaya, Recep Bingol, Cetin Kasapoglu

Open access · goldAbstract read
In one paragraph

Article in Current therapeutic research, clinical and experimental, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Ankaferd hemostat: from molecules to medicineTurkish journal of medical sciences · 2020
    Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sevgi CiftciDepartment of Microbiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Fahriye KeskinDepartment of Microbiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Sema Keceli OzcanDepartment of Microbiology and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Mehmet Ali ErdemDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Burak CankayaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Recep BingolDepartment of Microbiology and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Cetin KasapogluDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Istanbul University · TRKocaeli Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCandida albicans is a memeber of the oral flora that can lead to various complications in immunosupresive patients after oral surgery processes. Ankaferd Blood Stopper® (ABS) is a medical plant extract that is safe to use in patients with dental surgery bleedings in Turkey.

objectiveThe study evaluated the antifungal activity of ABS medicinal plant extract against C albicans using the agar diffusion and broth microdilution methods.

methodsThe plant extract antifungal activity was assessed in vitro either by applying the ABS extract directly and by applying different concentrations of ABS onto Candida culture. For these experiments, an agar diffusion method was used. To determine the minimum inhibitory concentration (MIC), a broth microdilution method was used.

resultsDifferent volumes of the active substance (10, 20, 30, and 40 μL) were applied onto Candida (0.5 McFarland solution) cultivated plate; Candida growth was inhibited in accordance with the volumes of ABS. However, when various dilutions of ABS (1:2, 1:20, 1:40, and 1:80) were added as drops containing 20 μL, no antifungal effects were found. No MIC values were identified using broth microdilution. When different dilutions of ABS containing 100 μL of 0.5 McFarland solution of C albicans were cultured depending on the time (10, 20, 30, and 40 minutes), the effect of the duration was not significant.

conclusionThe various tests were carried out to investigate antifungal effects of ABS on Candida, but none were found.

Indexed as

Ankaferd Blood Stopperantifungal activityCandidain vitro

Identifiers

PMID24648581
PMCPMC3957156
OpenAlexW2063435213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.