ArticleJournal of clinical microbiology2014
Deriving group A Streptococcus typing information from short-read whole-genome sequencing data.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes.Emerging infectious diseases · 2016Pooled it
- Dominance of the ST20Microorganisms · 2026Article
- Article
- Promiscuous evolution of Group A Streptococcal M and M-like proteins.Microbiology (Reading, England) · 2023Article
- Application of the random forest algorithm to Streptococcus pyogenes response regulator allele variation: from machine learning to evolutionary models.Scientific reports · 2021Article
- Cryptic prophages within aMicrobial genomics · 2021Article
- Analysis of Global Collection of Group AmSphere · 2020Article
- In silico characterisation of stand-alone response regulators of Streptococcus pyogenes.PloS one · 2020Article
- Article
- Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.Nature genetics · 2019Article
- Molecular Epidemiology, Ecology, and Evolution of Group A Streptococci.Microbiology spectrum · 2018Review
- Article
- PrevalentFrontiers in public health · 2018Article
- In silico characterisation of the two-component system regulators of Streptococcus pyogenes.PloS one · 2018Article
- Epidemiological and Molecular Characterization of an Invasive Group A StreptococcusJournal of clinical microbiology · 2017Article
- Whole genome sequencing of group APeerJ · 2017Article
- International circumpolar surveillance interlaboratory quality control program for emm typing of Streptococcus pyogenes, 2011-2015.Diagnostic microbiology and infectious disease · 2016Article
- Determining Streptococcus suis serotype from short-read whole-genome sequencing data.BMC microbiology · 2016Article
- Epidemiology of Invasive Group A Streptococcal Disease in Alaska, 2001 to 2013.Journal of clinical microbiology · 2016Article
- Whole-genome Sequencing for Surveillance of Invasive Pneumococcal Diseases in Ontario, Canada: Rapid Prediction of Genotype, Antibiotic Resistance and Characterization of Emerging Serotype 22F.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Typing of group A Streptococcus (GAS) is crucial for infection control and epidemiology. While whole-genome sequencing (WGS) is revolutionizing the way that bacterial organisms are typed, it is necessary to provide backward compatibility with currently used typing schemas to facilitate comparisons and understanding of epidemiological trends. Here, we sequenced the genomes of 191 GAS isolates representing 42 different emm types and used bioinformatics tools to derive commonly used GAS typing information directly from the short-read WGS data. We show that emm typing and multilocus sequence typing can be achieved rapidly and efficiently using this approach, which also permits the determination of the presence or absence of genes associated with GAS tissue tropism. We also report on how the WGS data analysis was instrumental in identifying ambiguities present in the commonly used emm type database hosted by the U.S. Centers for Disease Control and Prevention.
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